14. Amyloidosis

Question 1

You have a patient with localized amyloidosis. The affected organ has gross morphological changes- most notably tapioca-like granules or sago. What organ is affected? (MG)

A. Kidney
B. Spleen
C. Heart
D. Brain

Answer 1

B. Spleen

Question 2

A 77 year old male presents to the clinic with shortness of breath and chest pain. Upon physical examination you detect an arrhythmia and cardiomegaly. You perform a myocardial biopsy and see that the tissue is pale and waxy. The diagnosis is a condition in which misfolded protein deposits in what cellular compartment? (MG)

A. Intracellular fluid
B. Extracellular matrix
C. Mitochondrial matrix
D. Nucleus
E. Bone marrow

Answer 2

B. Extracellular matrix

Question 3

A 69 year old man is being treated in the ER causes he was hit by a car. His wife come in and tells you that he has been losing his memory for several years. You look and his chart and confirm he was diagnosed with Alzheimer’s disease 12 years ago. What is characteristic of this condition?

A . B2 Amyloid
B. AA Amyloid
C. Transthyretin 
D.AL amyloid
E. B2 microglobulin 

RFA

Answer 3

Ans. A. B2 Amyloid- is associated with Alzheimer’s

B. AA Amyloid- Chronic inflammatory diseases

C. Transthyretin- familiar neuropathy

D. AL- B cell diseases

E. B2 microglobulin- dialysis

Question 4

A patient comes to the hospital complaining of frequent urination. After urine testing it is noted that protein is found in the urine. It is believed that the patient is in the early stages of kidney failure. A biopsy of the kidney is taken and put under polarized light. What is the expected display if the patient is suffering from amyloid deposits in their kidneys.

A.Shiny Silver 
B. Apple Green
C. Salmon-Red 
D Glassy Pink 
E. Carrot Orange 

RFA

Answer 4

Ans. B. Amyloid will appear apple green in polarized light

A. Shiny Silver- not a thing

C. Salmon Red- how amyloid appear in a congo red stain

D. Glassy Pink- how amyloid appears in a H&E stain

E. Carrot Orange- Not a thing