22. Path of Neoplasia III Flashcards
Your patient has been diagnosed with osteosarcoma. You take cells from his femur and send them to the lab for immunocytochemistry. What type of immunohistochemical stain will be used?
A. Keratin B. Vimentin C. Desmin D. Chromogranin E. S-100
SZ
Ans. B Vimentin
Vimentin stains mesenchyme tissue such as bone marrow and CT.
Keratin- epithelium
Desmin- Muscle
Chromogranin- Neuroendocrine cells
S-100, HMB45, Melan A- Melanoma
Which of the following mutations makes someone susceptible to Hereditary non-polymosis CA?
A. MEN1 B. p53 C. APC D. MLH1 E. RET
SZ
Ans. D MLH1
MLH1, MSH2, MSH6, PMS2 are all linked to Hereditary non-polyposis colon CA.
MEN1 and RET - Multiple endocrine neoplasia
p53- Li-Fraumenii Syndrome
APC- Familial adenomatous polyposis
Henry is a 55 year old retired truck driver. He has just been given a recent diagnosis of adenocarcinoma. What is most reliable way to make a cancer diagnosis?
A. CT scan B. Blood/ Serum Test C. Genetic Screening D. Physical Examination E. Microsoptic tissue examination
RFA
Ans. E Microspotic tissue examination
A 37 year old woman has a tumor and during lab analysis it is found to staind with Chromogranin what tissue origin is the tumor?
A. Thyroid Follicular cells B. Mesenchyme C. Muscle D. Neuroendocrine cells E. Epithelium
RFA
Ans. D. Neuroendrocrine cells- Chromogranin
A. Thryoid Follicular cells- Thryoglobulin
B. Mesenchyme- Vimentin
C. Muscle- Desmin
E. Epithelium- Keratin
The autosomal recessive syndrome of defective DNA repair that can result in squamous cell carcinoma is
A. Ataxia telengiectesia
B. Xeroderma pigmentosa
C. Fanconi’s anemia
D. Li Fraumeni’s Syndrome
MG
B. Xeroderma pigmentosa
When it’s Sqkin think squamous
The two best ways to fix tissue when preparing a microscopy sample is with formalin or ____
A. Acetone
B. Formamide
C. Gluteraldehyde
D. Toluene
MG
C. Gluteraldehyde
