18. Pathology of Neoplasia

Question 1

A 72 year old man is diagnosed with a malignant tumor which of the following is a possible diagnosis with this given information?

A. Adenoma 
B.  Leiomyoma 
C. Lymphoma 
D.  Fibroma 
E.  Papilloma 

RFA

Answer 1

Ans. C Lymphoma- is the only malignant tumor listed. All other follow the “oma” is benign rule. The other exception is melanoma.

Question 2

A cell of mesenchymal of origin has developed into a tumor and has grow to and began to metastasis. What pathway is true of the pathway for this tumor to metastasis?

A. Travel via Seeding
B. Will travel in Lymphatics
C. Peritoneal cavity is most common site of this Pathway
D. Will travel in blood vessels

RFA

Answer 2

Ans. D. Since the tumor has mesenchymal origin it is most likely a sarcoma which mostly travel blood vessels

A. Travel via Seeding- is seen in Ovarian Carcinoma.

B. Will travel in Lymphatics- this is common in carcinomas, which are epithelial in origin

C. This is describing- Seeding

Question 3

In Turner’s syndrome, which type of “plasia” would you see with the patient’s ovaries? (MG)

A. Aplasia
B. Hypoplasia
C. Anaplasia
D. Dysplasia
E. Hyperplasia
F. Neoplasia

Answer 3

A. Aplasia

Rudimentary streak of ovaries in Turners

Question 4

You are given a tissue sample from the cervix of a patient with cervical carcinoma. You note keratin pearls in the sample. What stage of differentiation is the tumor in? (MG)

A. Well differentiated
B. Medium differentiation
C. Poorly differentiated
D. There is not enough info to answer this question

Answer 4

A. Well differentiated

Squamous cells of cervix. Squamous cells make keratin, so this is an example of good functional differentiation

Question 5

Which of the following can be used to measure tumor growth?

A. Nuclear pleomorphism
B. Cellular pleomorphism
C. Anaplasia
D. Mitotic Count
E. Ki67
F. A & C
G. D & E

SZ

Answer 5

Answer. G

Mitotic count and proliferation marker Ki67 are both used to measure tumor growth.

The remaining answer choices are characteristics of dysplasia.

Question 6

Which of the following terms describes disorganized normal tissue?

A. Aplasia
B. Hypoplasia
C. Choristoma
D. Hamartoma
E. Agenesis 

SZ

Answer 6

Ans. D Hamartoma

A. Aplasia- absence of organ
B. Hypoplasia- reduced size due to incomplete develop
C. Choristoma- ectopic rest
E. Agenesis- complete lack of organ