25. Path of Pituitary & Hypothalamus

Question 1

A 55 year old male visits his PCP with complaints of unrelenting headaches and loss of peripheral vision. Examination of his retinas shows papilloedema. He has no history of other medical conditions. CT reveals a large growth by the sella turica pushing against his optic chiasm. The genetic mutation causing his condition is causing an excess of what protein? (MG)

A. cAMP
B. cGMP
C. GTP
D. Ras
E. TRH

Answer 1

A. cAMP

Question 2

A 29 year old women is comes to her doctor with complaints of polyuria and thirst. Urine was tested at 220 mOsmol/kg. After treatment with vasopressin urine was 280 mOsmol/kg. What could have possibly cause this problem?

A. Steroid abuse 
B. Pituitary stalk lesion 
C. Oral contraceptive pills 
D. Pneumonia infection 
E. Lithium use

RFA

Answer 2

Ans. E Lithium- the patient has Nephrogenic DI ( vasopressin didn’t get urine osmo over 600) which can be causes by Lithium use

A. Steroid abuse- can result in decrease in testosterone production

B. Pituitary stalk lesion- would cause Central DI

C. Oral contraceptive- can cause hyperprolactinemia

D. Pneumonia infection- SIADH can be a complication after Pneumonia infection.