Topical preparations Flashcards
adminstered where
tissue surface
treat ……. condition
local
site of action is site of …………. action
therapeutic
to minimise side effect minimise
systemic absorption
pros of this route
avoid GI degradation
non-invasive
minimise side effect
conveinant
cons of ths route
low skin permeability
skin irritation
ointment:
drug dissolved
occulusve
creams:
semi-solid emulsion
multiphase dispersion
longer residence time than lotion
gel:
semi-solid
mostly aqueous
lotion:
water based
foam: dispersion of …….. within a ………..
gas
liquid
spray: fine mist generated using ………. in ………… can
propellant
pressurised
SA of human skin
2m2
epidermis has
stratueum corneum
corneocytes are what
hydophilllic
transcelllar route used for
hydrophillic drugs
paracellular route
lipophillic drugs
factors affecting dermal drug transport
drug properties:
-lipophillic
-moecular weight
anatomical site
