route of admin: aural and nasal

Question 1

therapeutic areas for nasal drug delivery

Answer 1

local

systemic

Question 2

local delivery

Answer 2

nasal allergy
nasal congestion
nasal infection

Question 3

systemic therapy

Answer 3

vaccine delivery

acess to CNS

Question 4

adv of nasal

Answer 4

easy to admin
non-inv
avoid 1st pass
low enzyme act

Question 5

nasal anatomy

Answer 5

divided to 2 halves by nasal septum

covered w mucous membrane containing goblet cells secreting mucus

Question 6

polar drugs will pass through ……… via gaps between the cells

Answer 6

epithelia

Question 7

olfactory mucosa is in contact with the

Answer 7

brain and cerebral spinal fluid

Question 8

drug can be absorbed across

Answer 8

olfactory mucosa and enter CNS

Question 9

large particles trapped in ……. …….. and undergo….. ……….

Answer 9

nasal filter

rapid clearance

Question 10

factors which affect systemic absorption

Answer 10

solubility

lipophilicity/hydrophilicty

Question 11

lipophillic drugs are …… absorbed from …………. cavity by ……………. route

Answer 11

rapidly
nasal
transcellular

Question 12

hydrophilic drugs are absorbed via ……….. route and ……… area for ………..

Answer 12

paracellular
smaller
absorption

Question 13

drugs with molecular mass <1 have

Answer 13

efficient absorption

Question 14

nasal mucosa surface has Ph of

Answer 14

7.5

Question 15

unionised drug mol w higher log P better abs than ionised form
true/false

Answer 15

true

Question 16

nasal spray

Answer 16

solution

suspension