Biopharmaceutics

Question 1

what does dosage-form design affect

Answer 1

drug absorption

therapeutic effect and safety.

Question 2

if there is an increases drug concentration in plasma there is ………. drug concentration at target site and …… pharmacological effect

Answer 2

increases

increased

Question 3

what does ADME stand for

Answer 3

absorption
distribution
metabolism
excretion

Question 4

what is the subtherapeutic range

Answer 4

range below the minima effective concentration

Question 5

what does fu stand for

Answer 5

unbound drug fraction

Question 6

what is the bioavailability of an IV admin

Answer 6

f=1

Question 7

what is the bioavailability of an oral admin

Answer 7

f<1

Question 8

what is the absorption rate depend on

Answer 8

permeability

solubility

Question 9

in the apical side

Answer 9

tight junction

adherance

Question 10

in the basolateral side

Answer 10

desmomes

gap

Question 11

small intestine

Answer 11

ph 5-7
SA-200m2
FV 120-350ml
transit time: 3-4H

Question 12

stomach

Answer 12

ph 1-2(fast)
4-5 (fed)
SA-0.053m2
FV 50ml
Transit time: 0-3H

Question 13

Large intestine

Answer 13

ph 6-7.5
SA 0.035m2
FV 10-200ml
Transit time: highly variable

Question 14

Bioavailability:

oral dose—-> excretion (????% )

Answer 14

15

Question 15

oral dose ——-> degradation (?????%)

Answer 15

15

Question 16

intestine wall:

fa ???% —–> int. metabolism ???%

Answer 16

70

20

Question 17

liver:

fi ????% ——> 1st pass metabolism ???%

Answer 17

80

50

Question 18

sys circulation:
fh ?????%
f ???%

Answer 18

50

28