drug toxicology Flashcards
what is toxiology
study adverse effects of chemicals on living systems
in toxicology you discover
new drugs and pesticides
adverse drug reactions are those which are ……… effect of a drug which occur at doses used in humans for ………
undesired
diagnosis
Type A is induced by same ………… mechanisms
pharmacological
Type A ……. of therapeutic effect of drugs
increase
Type A is………. dose dependant
directly
Type A intervention
dose reduction
Type A prevention
dose titration
adverse effects of B
develop of basis of :
- allergy
- idiosyncratic reactions
adverse effects of B
more serious clinical outcomes and higher overall mortality
in allergic reactions such as Type B the binding of drug on macromolecular carrier
covalent bond is needed
carrier is protein
goals of a pre-clinical safety assessment
establish dose-response and exposure response relationship
toxicology areas
mechanistic
descriptive
regulatory
mechanism based pharmacology
activation of target cause unwanted effecrs as well as therapeutic effects
dose response
LD50
TD50
ED50
IC50
