pharmacokinetics Flashcards
journey of drug through body
which bit is pharmacokinetic and what is pharmacodynamic
dose plasma conc target site effect clin outcome
top 2 is kinetic
rest dyamic
LADME
liberation absorption distribution metabolism elimination
at Cmax what is equal
abs and elim
Dl
initial dose
Cmax
max plasms conc
tmax
time to reach cmax
Vd
dist volume
C
plama conc
Dl=V x C is this right
yaa
admin is split into
systematic and topical
what uses circulatory system to distribute the drug
sys
which one is where the whole body is exposed to the drug
sys
parameters influencing abs
physiochem prop of drug
admin route
passive diffusion follows
first order kinetic
fac diffusion uses
channel/carrier protein
active transport will follow
michaelis-menten kinetics
different types of act trans
uniport
antiport
uniport coupled w a symport
uniport
transport of a single drug
facilitate mode of diffusion accelarating a reaction that is thermodynamically favoured
endocytosis
phagocytosis
pinocytosis
rec-med endocytosis
phagocytosis
process of innate immune response and bridge between innate and acquired immune response
pinocytosis
micropinocytosis
macropinocytosis
Factors which influence bio availability
salt factor
bioequality
physiochem prop
co-admin of other drug
presence of cormobidity affecting abs sites
susceptible to gastric acid and digestive enzyme
degree of metabolism in gut mucosa and 1st pass
salt factor
drugs not soluble therefore low bioavailability
increase sol, form as salt
bioequality
ensure all drug has same bioav
what needs to be same in bioeq
Cmax, tmax and AUC
first pass effect s directly after ……… before reaching circ system
abs
blood flow dependant on
exercise
shock
drug binding
ionic bound
H bound
in plasma protein binding the drugs are held in plasma by
albumin
lipoprotein
a-acid glycoprotein
FU=
unbound conc/total drug conc
dist vol
Vd=D/C
Vd depend on
body weight
plasma protein bind
Cap beds are
contiuous
fenestrated
sinusoid
biotrasnfrmation in heptocytes
xeniotic
active metabolism
conjugate
excrete
phase 1 included
func groups
phase 1 has enzymes located in
SER
enzymes in phase 1
oxygenases
reductases
hydrolytic enzymes
what is a prodrug
compound after admin metabolised into active compound
rate at which substrate is converted depnds on
turn over number
phase 2 `
catalysed by transferase
@ low conc- sulfonation faster
