pharmacokinetics

Question 1

journey of drug through body

which bit is pharmacokinetic and what is pharmacodynamic

Answer 1

dose
plasma conc
target site
effect
clin outcome 

top 2 is kinetic
rest dyamic

Question 2

LADME

Answer 2

liberation 
absorption
distribution
metabolism
elimination

Question 3

at Cmax what is equal

Answer 3

abs and elim

Question 4

Dl

Answer 4

initial dose

Question 5

Cmax

Answer 5

max plasms conc

Question 6

tmax

Answer 6

time to reach cmax

Question 7

Vd

Answer 7

dist volume

Question 8

C

Answer 8

plama conc

Question 9

Dl=V x C is this right

Answer 9

yaa

Question 10

admin is split into

Answer 10

systematic and topical

Question 11

what uses circulatory system to distribute the drug

Answer 11

sys

Question 12

which one is where the whole body is exposed to the drug

Answer 12

sys

Question 13

parameters influencing abs

Answer 13

physiochem prop of drug

admin route

Question 14

passive diffusion follows

Answer 14

first order kinetic

Question 15

fac diffusion uses

Answer 15

channel/carrier protein

Question 16

active transport will follow

Answer 16

michaelis-menten kinetics

Question 17

different types of act trans

Answer 17

uniport
antiport
uniport coupled w a symport

Question 18

uniport

Answer 18

transport of a single drug

facilitate mode of diffusion accelarating a reaction that is thermodynamically favoured

Question 19

endocytosis

Answer 19

phagocytosis
pinocytosis
rec-med endocytosis

Question 20

phagocytosis

Answer 20

process of innate immune response and bridge between innate and acquired immune response

Question 21

pinocytosis

Answer 21

micropinocytosis

macropinocytosis

Question 22

Factors which influence bio availability

Answer 22

salt factor
bioequality
physiochem prop
co-admin of other drug
presence of cormobidity affecting abs sites
susceptible to gastric acid and digestive enzyme
degree of metabolism in gut mucosa and 1st pass

Question 23

salt factor

Answer 23

drugs not soluble therefore low bioavailability

increase sol, form as salt

Question 24

bioequality

Answer 24

ensure all drug has same bioav

Question 25

what needs to be same in bioeq

Answer 25

Cmax, tmax and AUC

Question 26

first pass effect s directly after ……… before reaching circ system

Answer 26

abs

Question 27

blood flow dependant on

Answer 27

exercise

shock

Question 28

drug binding

Answer 28

ionic bound

H bound

Question 29

in plasma protein binding the drugs are held in plasma by

Answer 29

albumin
lipoprotein
a-acid glycoprotein

Question 30

FU=

Answer 30

unbound conc/total drug conc

Question 31

dist vol

Answer 31

Vd=D/C

Question 32

Vd depend on

Answer 32

body weight

plasma protein bind

Question 33

Cap beds are

Answer 33

contiuous
fenestrated
sinusoid

Question 34

biotrasnfrmation in heptocytes

Answer 34

xeniotic
active metabolism
conjugate
excrete

Question 35

phase 1 included

Answer 35

func groups

Question 36

phase 1 has enzymes located in

Answer 36

SER

Question 37

enzymes in phase 1

Answer 37

oxygenases
reductases
hydrolytic enzymes

Question 38

what is a prodrug

Answer 38

compound after admin metabolised into active compound

Question 39

rate at which substrate is converted depnds on

Answer 39

turn over number

Question 40

phase 2 `

Answer 40

catalysed by transferase

@ low conc- sulfonation faster