Immune system 2 Flashcards
induced innate IR
toll like receptors
NK cells
how many subtypes of toll-like receptors are there
10
what activates TLR in macrophages
LPS
whan a bacterium binds to the receptor and simulates a signal transduction path it will activate
NF-RB
Name the three stages of an interferon response
virus-infected cells
IFN-a IFN B
interferon response
what can the interferon response do
induce resistance to viral replication in all cells
include expression of ligands for receptors on NK cells
activate NK cells to kill virus infected cells
variable region has ……. and ……. and have ……. binding
Vh
Vl
Fab binding
IgG IgD IgA has ………… domain
3 Ch
IgM, IgE, have ……… domain
4
what is the light chain made of
λ & κ
what is heavy chain made of
γ,µ,δ,α,ε
what shape is IgA
dimer
what shape is IgM
pentamer
NK cells:
IFN binds to IFN receptors and activates them
NK cells proliferate and differentiate into
effector NK cells
what do effector NK cells kill
virus-infected cells by apoptosis
what does the bacteria do in the innate IR which is different to virus innate IR
phagocytosis compare to interferons Type 1
which TLR does innate immune response use in bacteria
TLR 12459
which TLR does innate immune response use in virus
TLR 3789
what is IgE commonly associated with
allergy
parasites
what is IgA commonly associated with
prevent septicaemia
breast milk
what shape is IgM
pentameric
what is IgM associated with
1st antibody made
primary response
what is IgG associated with
2nd response
prevent septicaemia
