Route Of Admin(tablets) Flashcards

1
Q

Ph of stomach

A

Ph 1-2 fasted

4-5 fed

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2
Q

Surface area of stomach

A

0.05m2

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3
Q

Transit time of the stomach

A

0-3h

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4
Q

Ph of the small intestine

A

5-7

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5
Q

Surface area of small intestine

A

200m2

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6
Q

Transit time of small intestine

A

3-4h

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7
Q

Ph of large intestine

A

6-7.5

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8
Q

Surface area of large intestine

A

0.35m2

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9
Q

Oral route advantages

A

Simple and safe

High SA to absorb

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10
Q

Disadvantages of oral route

A

1st pass

Hostile environment

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11
Q

Adv of tablets

A

Precise drug dose

Better chem stability

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12
Q

Disintegrating tablet

A

Release drug in short time to aid fast and drug release

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13
Q

What do disintegrating tablets do

A

Release drug in short time to aid fast and drug release

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14
Q

Where do gastro resistant tablets release drugs

A

In the intestinal fluid

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15
Q

What kind of dispersion do dispersive tablets make

A

Homogenous

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16
Q

Tablet manufacturing - 3 steps

A

Die filling
Tablet formation
Tablet ejection

17
Q

2 different types of tablet press

A

Single press

Rotary press

18
Q

What do you need to control in powder mix properties

A

Homogeneity and segregation tendency
Flow ability
Compression and compaction
Friction and adhesive properties

19
Q

What filler is most normally used

A

Lactose

20
Q

What disintegrat is normally used

A

Starch