Route Of Admin(tablets) Flashcards
Ph of stomach
Ph 1-2 fasted
4-5 fed
Surface area of stomach
0.05m2
Transit time of the stomach
0-3h
Ph of the small intestine
5-7
Surface area of small intestine
200m2
Transit time of small intestine
3-4h
Ph of large intestine
6-7.5
Surface area of large intestine
0.35m2
Oral route advantages
Simple and safe
High SA to absorb
Disadvantages of oral route
1st pass
Hostile environment
Adv of tablets
Precise drug dose
Better chem stability
Disintegrating tablet
Release drug in short time to aid fast and drug release
What do disintegrating tablets do
Release drug in short time to aid fast and drug release
Where do gastro resistant tablets release drugs
In the intestinal fluid
What kind of dispersion do dispersive tablets make
Homogenous
Tablet manufacturing - 3 steps
Die filling
Tablet formation
Tablet ejection
2 different types of tablet press
Single press
Rotary press
What do you need to control in powder mix properties
Homogeneity and segregation tendency
Flow ability
Compression and compaction
Friction and adhesive properties
What filler is most normally used
Lactose
What disintegrat is normally used
Starch
