cell signalling 1 Flashcards
what do transport proteins do
alter ion transport
what do metabolic enzymes do
alter metabolism
what do gene- regulator proteins do
alter gene expression
what do cytoskeletal proteins do
alter cell shape/movement
what do cell cycle proteins do
alter cell growth and division
Give two examples of ligand-gated ion channels
nicotinic acetylcholine receptor
gaba amino-butyric acid
what exact type of receptor is a nicotinic acetylcholine receptor
ionotropic receptor
what enters when nicotinic acetylcholine receptor is activated
na which binds to nicotine
sometimes ca
what exact type of receptor is a gaba receptor
inhibitory
what enters when gaba receptor is activated
CI- ions
what activates gaba receptor
CNS neurotransmitter ( amino-butyric acid)
alcohol
benziodiazepem
is ACH more sensitive to muscarinic or nicotinic
muscarinic
in G protein gated channels how many polypeptide chains are found
3: alpha beta gamma
what can the alpha subunit bind
GTP/GDP
what has higher affinity for By : a-GDP or a-GTP
a-GDP
how many transmembrane domains do G proteins have
7
how many genes encode for Protein receptors
800
recite the G protein cycle
- unstimulated cell
- adrenaline bind to B-adrenoreceptor
- allow B-adrenoreceptor/ G protein interaction
- Allow GTP/GDP exchange
- Allow a-subunit liberation
- Free a subunit activate AC
- Unbinding of adrenaline/GTP hydrolysis.
what do these receptors couple to:
B-adrenoreceptors
vasopressin
A2A/B adenosine receptors
couple to Gs
what does cholera toxin act on
a subunit
what does cholera toxin cause to happen
ADP-ribosylation
