cell signalling 1 Flashcards

1
Q

what do transport proteins do

A

alter ion transport

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2
Q

what do metabolic enzymes do

A

alter metabolism

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3
Q

what do gene- regulator proteins do

A

alter gene expression

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4
Q

what do cytoskeletal proteins do

A

alter cell shape/movement

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5
Q

what do cell cycle proteins do

A

alter cell growth and division

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6
Q

Give two examples of ligand-gated ion channels

A

nicotinic acetylcholine receptor

gaba amino-butyric acid

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7
Q

what exact type of receptor is a nicotinic acetylcholine receptor

A

ionotropic receptor

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8
Q

what enters when nicotinic acetylcholine receptor is activated

A

na which binds to nicotine

sometimes ca

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9
Q

what exact type of receptor is a gaba receptor

A

inhibitory

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10
Q

what enters when gaba receptor is activated

A

CI- ions

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11
Q

what activates gaba receptor

A

CNS neurotransmitter ( amino-butyric acid)
alcohol
benziodiazepem

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12
Q

is ACH more sensitive to muscarinic or nicotinic

A

muscarinic

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13
Q

in G protein gated channels how many polypeptide chains are found

A

3: alpha beta gamma

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14
Q

what can the alpha subunit bind

A

GTP/GDP

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15
Q

what has higher affinity for By : a-GDP or a-GTP

A

a-GDP

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16
Q

how many transmembrane domains do G proteins have

A

7

17
Q

how many genes encode for Protein receptors

A

800

18
Q

recite the G protein cycle

A
  1. unstimulated cell
  2. adrenaline bind to B-adrenoreceptor
  3. allow B-adrenoreceptor/ G protein interaction
  4. Allow GTP/GDP exchange
  5. Allow a-subunit liberation
  6. Free a subunit activate AC
  7. Unbinding of adrenaline/GTP hydrolysis.
19
Q

what do these receptors couple to:
B-adrenoreceptors
vasopressin
A2A/B adenosine receptors

A

couple to Gs

20
Q

what does cholera toxin act on

A

a subunit

21
Q

what does cholera toxin cause to happen

A

ADP-ribosylation