ROA inhaled

Question 1

lung has a large

Answer 1

SA

Question 2

does inhaled drug delivery have direct and rapid action

Answer 2

yes

Question 3

the air blood barrier is thin so there is better drug permeability true/false

Answer 3

true

Question 4

advantages of this route

Answer 4

smaller doses
fast
avoid 1st pass

Question 5

disadvantages of this route

Answer 5

complex drug delivery
devices hard to use
reliability is low as drug delivery is slow
drug absorption limited by mucous layer

Question 6

how many phases in aerosols

Answer 6

2

Question 7

how does aerosols work

Answer 7

deposition
dissolution
absorption

Question 8

what does drug deposition depend on

Answer 8

physiochemical properties of the drug
formulation
aerosol device
patient

Question 9

3 main mechanism for drug deposition

Answer 9

gravitational sedimation
Brownian diffusion
inertial impaction

Question 10

patient factors which affect particle deposition

Answer 10

lung physiology
breathing pattern
presence of pulmonary disease

Question 11

what does the drug powder have to do first

Answer 11

dissolve in the mucus layer before absorption

Question 12

once the drug is on solution it will diffuse through …… and enter ……. environment

Answer 12

mucus

aqueous

Question 13

what is the rate limiting step

Answer 13

dissolution

Question 14

physiochemical factors

Answer 14

aerodynamic size of drug particle
aerodynamic diameter of irregular particle is diameter of perfect particle
shape and physical stability also affects deposition

Question 15

drug absorption only occurs when

Answer 15

dissolution is faster than clearance