Route of Admin rectal/vaginal

Question 1

what drug delivery is this used for

Answer 1

local

systemic

Question 2

how much mucus is in rectum

Answer 2

3ml

Question 3

SA of rectum

Answer 3

300m2

Question 4

pH of rectum

Answer 4

ph 7.5

Question 5

how are drugs normally absorbed recally

Answer 5

passive diffusion

Question 6

after absorption where does the drug enter

Answer 6

haemorrhoid veins

Question 7

lower and upper haemorrhoid veins will drain to

Answer 7

systemic circulation

Question 8

upper haemorrhoid veins drain to

Answer 8

portal veins

Question 9

physiological factors

Answer 9

quantity of rectal fluid
properties of rectal mucus
rectum contents
motility of rectal wall

Question 10

release mechanism

Answer 10

sedimentation
wetting
dissolution 
melting 
spreading

Question 11

advantages

Answer 11

remove dosage form and discontinue treatment

suitable to drugs which could be degraged in GIT

Question 12

Different formulations of rectal dosage forms

Answer 12

suppositories
foams
solution-suspension-emulsion

Question 13

disadvantages

Answer 13

patient acceptability is low

drug abs is slow

Question 14

in fatty bases what hydrophilic bases are used

Answer 14

glycerol-gelatine

Question 15

higher the gelatine proportion the more

Answer 15

rigid and longer acting the formulation

Question 16

what excipients are normally used

Answer 16

surface-active agents

controlling agents

Question 17

drug absorbed through systemic action are absorbed by

Answer 17

passive transport

Question 18

advantages of vaginal administration

Answer 18

local effects

avoid 1st pass

Question 19

disadvantages of vaginal administration

Answer 19

gender

period affect it