Enzymes as drug targets Flashcards
1
Q
enzyme classifications
A
- oxireductases
- transferase
- hydrolases
- lysases
- isomerases
- ligases
2
Q
biological catalysts
A
change equilibrium position`
3
Q
enzymes as catalysts:
- provide …………….
- provide ………….
A
nucelophiles
active sites
4
Q
oxidoreductases will
A
catalyse redox reactions
5
Q
dehydrogenases accept and donate …. as …. atoms using …… such as ……..
A
e-
H
cofactors
NAD+
6
Q
kinases
A
transfer phosphate groups
7
Q
aminotransferases
A
transfer amino groups
8
Q
gylcosytransferases
A
transfer carb residues
9
Q
acyltransferases
A
transfer Fatty acyl groups
10
Q
Hydrolases
A
catalyse clevage of bonds by adding water molecules
11
Q
Chymotrypsin
A
prefer aromatic side chain adjactent to scissior bond of peptide
12
Q
Trypsin
A
prefer positive charged side chain whcih interacts w ASP 189
13
Q
lysases
A
clevage bonds using hydrolysis
14
Q
Isomerases
A
rearrange atoms/molecules
15
Q
ligases
A
synth bond between CONS
