receptor theory and class of drug acion

Question 1

4 main regulatory proteins

Answer 1

receptors
enzymes
carrier molecules
ion channels

Question 2

main receptor classes

Answer 2

intreacell receptor
enzyme-linked receptors
G-protein coupled receptors
ligand-gated ion channel

Question 3

how many attachement is need of a drug to a receptor site is required

Answer 3

3

Question 4

3 different binding studies

Answer 4

• kinetic
• saturation
• competiton/modulation

Question 5

radioreceptor assay:

Answer 5

measure binding of drugs to receptors

Question 6

agonist

Answer 6

interact with specific cell constituents

Question 7

ED50

Answer 7

effective dose to make 50% max response

Question 8

partial agonists

Answer 8

act on same receptor as agonists but can not produce same biological response

Question 9

inverse agonists

Answer 9

act on same receptors as agonist but inverse effect

Question 10

spare receptor

Answer 10

max responses are elicited at less than max receptor occupancy

Question 11

intrinsic activity

Answer 11

ability of agonist to activate receptor as compared to maximally active compound in series being studied

Question 12

antagonist

Answer 12

inhibits effect of agonist but 0 biological activity of its own may compete on the same receptor site that agonist occupies or may act on allosteric site

Question 13

different antagonists

Answer 13

competitive
noncomp
allosteric
physiological

Question 14

what does occupation theory say

Answer 14

drugs act on independent binding site and activate to make a biological response

Question 15

Rate theory:

Answer 15

response proportional to rate of drug-receptor complex formation

Question 16

heteroreceptor

Answer 16

regulates the release of chemical mediators other than its own ligand

Question 17

autoreceptor

Answer 17

found in nerve ending that regulates synth and release of own ligand

Question 18

receptor down regulation

Answer 18

agonist induces a decrease in number of receptors available for binding

Question 19

receptor up regulation

Answer 19

agonist induces increases in number f these receptors available for binding

Question 20

affinity is propertional to

Answer 20

Kd

Question 21

macromolecular perturbation theory

Answer 21

• aseptic conformational perubation leads to biological response
• nonspec conformational pertubation leads to 0 biological response

Question 22

activation-aggregation theory

Answer 22

suggests drug receptor still exists in equilibrium between activated state and in activated state

Question 23

2 state receptor models are developed on basis of

Answer 23

competitive and allosteric inhibition

Question 24

agonists have high affinity for

Answer 24

R* state

Question 25

class of drugs

Answer 25

chemotherapeutic agents
pharmacodynamic agents
miscellaneuos agents

Question 26

drug action mechanism

Answer 26

physcial

chemical

Question 27

ligands are

Answer 27

endogenous

Question 28

agonists can produce

Answer 28

chain reaction