Cell signalling 3

Question 1

Different types of enzyme linked receptors (5)

Answer 1

Receptor:

• guanylyl Cyclase
• Serine/Threonine Kinases
• Tyrosine Kinase
• Tyrosine kinase associated receptors
• tyrosine phosphate

Question 2

Receptor Guanylyl cyclase has how many domains

Answer 2

2

Question 3

what does Receptor Guanylyl cyclase convert

Answer 3

GTP-cGMP

Question 4

What does cGMP activate

Answer 4

downstream kinase

Question 5

in Receptor Guanylyl cyclase ANP is the first messenger. response to this signal is to ……. vascular smooth muscle and …… blood vessels and enhance ……. excretion.

Answer 5

relax
dilate
Na+

Question 6

what do the Serine/threonine kinases domains do to target proteins

Answer 6

phosphorylate

Question 7

how many domains do Tyrosine-kinase -ass receptors have

Answer 7

0

Question 8

How does the Tyrosine-kinase -ass receptors associate to the cytoplasmic domain

Answer 8

using non-covalent

Question 9

what is the 1st messenger of Receptor Tyrosine Kinase

Answer 9

insulin

Question 10

how many molecules of insulin does the receptor Tyrosine Kinase bind

Answer 10

2

Question 11

The receptor Tyrosine Phosphatase will …….. target proteins

Answer 11

dephosphorylate

Question 12

what is the first messenger in Tyrosine Phosphatase.

Answer 12

CD45

Question 13

2 different hormones in signal transduction

Answer 13

steroid

non-steroid

Question 14

what is water solube

Answer 14

non-steroid

Question 15

what can pass through plasma membrane

Answer 15

steroid

Question 16

what is slow acting

Answer 16

steroid

Question 17

in cytoplasmic receptor activation the ligand binding will dislodge what

Answer 17

regulatory protein

Question 18

what does cytoplasmic receptor activation allow for

Answer 18

gene transcription/ gene expression inhibition

Question 19

in nuclear receptor activation what does it allow to happen

Answer 19

make MRNA for proteins