Dissolution Testing

Question 1

transfer ………/,,,,,,,,,,, from ….. state to …..

Answer 1

moelcule ion
solid
solution

Question 2

evaluate …….. of release of drug sustenance from …… form

Answer 2

rate

dosage

Question 3

dissolution is process where ….

Answer 3

solute dissolve in solvent and make solution

Question 4

is dissolution thermodynamically favourable

Answer 4

yes

Question 5

to be spontaneous Gibbs free energy must be

Answer 5

negative

Question 6

Noes Whitney equation

Answer 6

sm/dt= da change in conc/ n

Question 7

rate of dissolution is controlled by

Answer 7

speed of removal particles from solid surface

diff rate of particle thorugh bondary layer which surrounds solid

Question 8

for a drug to be effective must be ……. from …….. …… and dissolve in ……. …….. before ……….. happens

Answer 8

released
dosage
form
GI
fluid
absorption

Question 9

in vitro diss testing;

measure the …… at which the ………….. is released from …… form and dissolves in ……… media

Answer 9

rate
API
dosage
dissolution

Question 10

factors affecting dissolution

Answer 10

intrinsic properties of API

formulation composition and characteristic

Question 11

dissolution testing used in

Answer 11

qc

predictive tests

Question 12

diffusion rate increases, if SA

Answer 12

increases

Question 13

how do you increase SA

Answer 13

use micro ionised particles

Question 14

paddle apparatus:

is similar to

Answer 14

similar to basket

Question 15

paddle apparatus: dissolution process occurs ……… the dissolution medium

Answer 15

throughout

Question 16

in a paddle apparatuse the dosage unit must what

Answer 16

sink to the bottom of the dissolution vessel

Question 17

in dissolution media what should you use for weak basic drugs

Answer 17

0.1M HCI

Question 18

in dissolution media what should you use for weak acidic drugs

Answer 18

phosphate buffer

Question 19

diss criteria:

immediate release

Answer 19

> 70%

Question 20

in extended release formulations what is the first phase

Answer 20

premature drug diss

Question 21

in extended release formulations what is the second phase

Answer 21

complete drug diss