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Microbiology > T Cell mediated Immunity- Activation of T cells > Flashcards

T Cell mediated Immunity- Activation of T cells Flashcards

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1
Q

Do effector or memory T cells die once the infection is gone?

A

Effector T cell

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2
Q

What 2 events are needed move the naive T cell to proliferation and eventually differentiation?

A

Antigen recognition and cytokine secretion

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3
Q

Antigen recognition needs to be aided by _____ in order to move the T cell activation process along

A

Costimulation

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4
Q

______ molecules on T cells stabilize binding to APCs

A

Adhesion

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5
Q

What is the integrin protein used as an adhesion molecule in activation of T cells?

A

LFA-1

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6
Q

What is the ligand used as an adhesion molecule in activation of T cells?

A

ICAM-1

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7
Q

The interaction of what 2 things are essential for naive T cells to secrete cytokines?

A

CD28 and B7

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8
Q

If there is no B7 bound to CD28, what is the T cell response?

A

No cytokines released, so no response or tolerance

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9
Q

What are the 2 inhibitory receptors of t cell activation?

A

CTLA-4 and PD-1

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10
Q

_____ that engulf virus infected cells (source of class II MHC peptides) and also are infected themselves (source of class I MHC peptides) will have antigens presented by both class I and II MHC molecules.

A

APCs

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11
Q

APCs that engulf virus infected cells (source of class II MHC peptides) and also are infected themselves engage what type of T cell?

A

CD4 and CD8

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12
Q

Which T cell helps to activate the other in the case of an APC that is infected with virus that has been engulfed?

A

CD4 T cell activates CD8

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13
Q

What receptor decreases the effector functions of T cells?

A

CTLA-4

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14
Q

_____ is the portion between the APC and T cell where cytokines stimulate activity in T cell membrane

A

Immunological synapse

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15
Q

What are 2 drugs used to prevent graft rejection that act on the signal transduction pathway in T cells?

A

Cyclosporine and Rapamycin

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16
Q

Most activation and inactivation in T cell occurs via what 2 processes?

A

Phosphorylation and de-phosphorylation

17
Q

Are TCR binding complexes membrane bound or cytoplasmic?

A

Both

18
Q

What types of antigens bind to TCR?

A

Protein antigens

19
Q

Principal function of ____ is survival and proliferation of antigen-specific T cells

A

IL-2

20
Q

What subunit that bonds to the T cell in the IL-2 receptor makes the complex much more useful and beneficial?

A

Alpha subunit

21
Q

______ cells remain in lymphoid organ and migrate into follicles; help b cells to produce high-affinity antibodies

A

Follicular helper t cells (Tfh)

22
Q

Subsets of CD4+ T cells are distinguished by their _____ profiles:

A

cytokine

23
Q

______ ligands are only expressed on activated T cells

A

CD40L

24
Q

The roles of ______ are:

  • macrophage activation and killing of phagocytosed microbes
  • secretion of antibodies with enhanced abilities to neutralize and eliminate antigens
A

CD40L

25
Q

What 3 types of things are necessary for exit from lymph tissue and important for naive T cells in lymph node to interact with lymphoid endothelium to migrate into lymphoid organ?

A

Selectin
integrin
Chemokine receptor

26
Q

Which selectin is necessary for naive T cells in lymph node to interact with lymphoid endothelium to migrate into lymphoid organ?

A

L selectin

27
Q

Which 2 selectins are necessary for t cell exit from lymph tissue?

A

E and P selectin

28
Q

Which integrin is necessary for naive T cells in lymph node to interact with lymphoid endothelium to migrate into lymphoid organ?

A

LFA-1

29
Q

Which 2 integrins are necessary for t cell exit from lymph tissue?

A

LFA-1 or VLA-4

30
Q

Which chemokine receptor is necessary for naive T cells in lymph node to interact with lymphoid endothelium to migrate into lymphoid organ?

A

CCR7

31
Q

Which chemokine receptor is necessary for t cell exit from lymph tissue?

A

CXCR3

32
Q

Does exit or entry by a t cell into or out of lymph node dependent on antigen recognition and more dependent on costimulation?

A

Entry

Microbiology (46 decks)

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