T cell effector funcitons

Question 1

Subsets of CD4+ helper T lymphocytes distinguished by_______ they produce

Answer 1

cytokines

Question 2

CD4+ helper T lymphocytes — Th1

Answer 2

INF y

Question 3

CD4+ helper T lymphocytes —- Th2

Answer 3

IL- 4,5,13

Question 4

CD4+ helper T lymphocytes —— Th17

Answer 4

IL- 17,22

Question 5

What cells to Th1 CD4+ helper T lymphocytes target?

Answer 5

macrophages

Question 6

What cells to Th2 CD4+ helper T lymphocytes target?

Answer 6

eosinophils

Question 7

What cells to Th17 CD4+ helper T lymphocytes target?

Answer 7

Neutrophils

Question 8

What is the function of cytokine IL-2?

Answer 8

t cell proliferation; regulatory T cell survival.

Question 9

What is the function of cytokine INF-y?

Answer 9

activation of macrophages

Question 10

What is the function of cytokine IL-4?

Answer 10

B cell switching to IgE

Question 11

What is the function of cytokine IL-5?

Answer 11

activation of eosinophils

Question 12

What is the function of cytokine IL-17?

Answer 12

stimulation of acute inflammation

Question 13

What is the function of cytokine IL-22?

Answer 13

maintenance of epithelial barrier function

Question 14

What is the function of cytokine TGF-b ?

Answer 14

inhibition of T cell activation; differentiation of regulatory T cells

Question 15

Th1 cell function:

Answer 15

classical macrophage activation (enhanced microbial killing)

Three results:

Killing of phagocytosed bacteria

increased expression of MHC and costimulators (b7 molecules)

Secretion of cytokines (TNF, IL- 1, 12, cehmokines)

Question 16

What induces Th2 cell function?

Answer 16

Induced by parasitic worm infections

Question 17

What are the signature cytokines of Th2 Cells.

Answer 17

IL-4, IL-5, IL-13

Question 18

What is the function of Th2 cells???

Answer 18

eosinophil activation

helminth death

Question 19

_______ _______ reactions are initiated by the introduction of an allergen, which stimulates TH2 reactions and immunoglobulin E (IgE) production

Answer 19

Immediate hypersensitivity

Question 20

T/F there is fluidity in the classes between Th1 and Th2 cells.

Answer 20

true

Question 21

T/F: In Th2 cell development IL-4 will allow the antigen activated T cell to autostimulate.

Answer 21

True

Question 22

What is the major function of Th17 cells?

Answer 22

Recruitment of neutrophils, resulting in inflammation

Question 23

_______ facilitates entry of granzymes into the cytosol, granzymes activate apoptosis.

Answer 23

Perforin

Question 24

What is the function of CD8+ cytotoxic T Lymphocytes

Answer 24

1. bind to target cell
2. become activated by target cell and release granules (granzymes)
3. apoptosis of target cell.