Antigen Capture and Presentation to Lymphocytes

Question 1

_____ protein displaced on surface of cells

Answer 1

MHC

Question 2

_____ can recognize lipids, nucleic acids, and other types of molecules; mainly recognize proteins

Answer 2

Antibodies

Question 3

___ t cells are involved in killing of infected cells

Answer 3

CD8+

Question 4

Antigens are initially captured by ____ cells

Answer 4

Dendritic cells

Question 5

Once antigens are captured, they are concentrated in ____ organs

Answer 5

Peripheral lymph organs

Question 6

______: used in antigen presentation to naive T cells in the initiation of T cell responses to protein antigens (priming)

Answer 6

Dendritic cells

Question 7

_____ are important for antigen presentation to by dendritic cells activate naive T cells

Answer 7

Costimulators

Question 8

Besides dendritic cells, what are 2 other important APCs?

Answer 8

Macrophages and B lymphocytes

Question 9

________ molecules are expressed on antigen-presenting cells and function to display peptides derived from protein antigens. Peptides bind to the molecules by anchor residues, which attach the peptides to pockets in the molecules. The receptor of every T cell recognizes some residues of the peptide and some (polymorphic) residues of the molecule.

Answer 9

Major histocompatibility complex (MHC)

Question 10

_____ bind to the MHC molecules by anchor residues, which attach the peptides to pockets in the molecules.

Answer 10

Peptides

Question 11

The receptor of every ____ recognizes some residues of the peptide and some (polymorphic) residues of the MHC molecule.

Answer 11

T cell

Question 12

____ was originally founded via tissue graft matching

Answer 12

MHC

Question 13

Polymorphic regions: a1 and a2
a3 binds T cell co-receptor
peptide-binding cleft for peptides 8-9 aa long

Answer 13

CD8+T cells

Question 14

____ can only respond to antigen presented by MHC class I molecules

Answer 14

CD8+T cells

Question 15

_____ can only respond to antigen presented by MHC class II molecules

Answer 15

CD4+T cells

Question 16

Polymorphic regions: a1 and b1
a2and b2 binds T cell co-receptor
Peptide-binding cleft for peptides 10-30 aa long

Answer 16

CD4+T cells

Question 17

Peptide-binding cleft for peptides 8-9 aa long in which T cell?

Answer 17

CD8+T cells

Question 18

Peptide-binding cleft for peptides 10-30 aa long

Answer 18

CD4+T cells

Question 19

T/F: Class I and class II MHC genes are the most polymorphic genes in the genome.

Answer 19

true

Question 20

The total number of HLA alleles in the human population is estimated to be about ____ class I alleles and _____ class II alleles.

Answer 20

10,000 class I alleles and 3,000 class II alleles.

Question 21

_____ expression of (MHC) alleles inherited from parents

Answer 21

Codominant

Question 22

_____ genes: many different alleles are present in the population

Answer 22

Polymorphic genes

Question 23

_______: both parental alleles of MHC gene are expressed

Answer 23

Co-dominant expression

Question 24

____ feature of MHC molecules: many different peptides can bind to the same MHC molecule

Answer 24

broad specificity

Question 25

____ feature of MHC molecules: class 1 and 2 MHC molecules display peptides from different cellular compartments

Answer 25

Peptides acquired during intracellular assembly

Question 26

____ feature of MHC molecules: only peptide-loaded MHC molecules are expressed on the cell surface for recognition by T cells

Answer 26

Stable surface expression of MHC molecule requires peptide bond

Question 27

____ feature of MHC molecules: MHC molecule displays bound peptide for long enough to be located by T cell

Answer 27

Very slow off-rate

Question 28

______ recognize endogenous (cytosolic) antigen presented by MHC class I molecules on an infected cell

Answer 28

CD8+Cytotoxic T cells (CTLs)

Question 29

______ exports peptides into ER to be recognized by MHC 1; also helps MHC 1 break free to be transported out to cell surface via golgi and exocytic vesicle

Answer 29

Tapasin

Question 30

_______ recognize exogenous antigen presented by MHC class II molecules on a professional antigen presenting cell (APC)

Answer 30

CD4+ Helper T cells

Question 31

Class I MHC-restricted cross-presentation of microbial antigens from infected cells by _____ cells

Answer 31

dendritic

Question 32

Class ____ MHC effector functions: macrophage activation: killing of phagocytosed microbe; B cell antibody secretion: antibody binding to antigen

Answer 32

Class 2 MHC

Question 33

Class ____ MHC effector functions: killing of antigen-expressing target cell

Answer 33

Class 1 MHC