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Microbiology > Gastro-Adeno-Papilloma > Flashcards

Gastro-Adeno-Papilloma Flashcards

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Biology 101 flashcards
1
Q

–Inflammation of stomach or intestines
–important disease of infants and children
–leading cause of childhood death in developing countries
- Mostly caused by rotaviruses

A

Viral Gastroenteritis (Chapter 37)

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2
Q

_____ is a segmented dsRNA virus that is the main cause of diarrhea in children 6-24 month

A

Group A rotavirus

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3
Q

_____ is (+) ssRNA and is the major cause of outbreaks in children and adults

A

Norovirus

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4
Q

_____ virus= 1st virus identified from stool samples by electron microscopic examination (1972)

A

Norwalk virus

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5
Q

Rotaviruses are members of the _____ family:

  • Nonenveloped
  • Inner and outer capsids
  • 11 segments of dsRNA = genome
  • lysis of infected cells
A

Reovirus family

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6
Q

_____ causes: -potentially fatal dehydration; fecal-oral transmission; watery-diarrhea

A

Rotaviruses

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7
Q

acid stability of rotaviruses is conferred by ______

A

double capsid structure

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8
Q

rotavirus produces an _____ that binds integrins; signaling results secretion of chloride and water-infected gut epithelial cells destroyed & replaced by immature epithelial cells (reduced uptake of ions, water; less absorption of foods molecules (carbs))

A

enterotoxin

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9
Q 
\_\_\_\_\_: positive strand RNA genome
~7,500 bases in length
Naked capsidvirions
-Replication similar to picornaviruses (poliovirus) except 2nd phase of translation involves subgenomicRNAs (like coronaviruses). 
-Has a 5VPgprotein on RNA
A

Noroviruses

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10
Q

______ virus:
linear double-stranded DNA genome
non-enveloped
icosahedral capsid

A

Adenovirus

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11
Q

Adenoviral _______ enters cell nucleus

A

nucleoprotein complex

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12
Q

T/F: Adenovirus gene expression temporal regulation pre-early, early, late genes

A

Tru

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13
Q

_________ are produced during one phase act to promote transcription of genes of subsequent phase (adenovirus)

A

transcriptional regulators

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14
Q

____ DNA replication only one of the 2 DNA strands is copied at each replication fork; no discontinuous replication (lagging strand replication)priming is by a viral protein, pTP (preterminal protein)

A

Adenovirus

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15
Q

What is the primer of adenovirus DNA replication?

A

Viral protein pTP

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16
Q

______ infections:

  • widespread: 5-10% of all viral infections
  • usual symptoms resemble common cold
  • Vaccine (live virus) given to new military recruits targets serotypes 4 and 7
A

Adenovirus

17
Q

acute respiratory disease (ARD) is caused by what serotypes of adenovirus?

A

4, 7

18
Q 
block MHC class I mRNA production
block transport of MHC class I proteins to the cell surface
viral E3gp19K protein does this (see next slide)
results in block of killing by cytotoxic T cells
A

Adenovirus

19
Q

_____ drives the host cell into cell division
necessary for the virus to replicate (needs cellular S phase factors)
E1a and E1b proteins interfere with cell division controllers
E1b sequesters p53
E1a sequesters Rb (retinoblastoma protein)
Viral infection can potentially drive a cell toward a cancerous state

A

Adenovirus

20
Q

Which Adenovirus protein sequesters p53?

A

E1B

21
Q

Which adenovirus protein sequesters Rb?

A

E1a

22
Q

P53 recognizes DNA damage and activates _____

A

P21

23
Q

_____ binds and inactivates the cyclin-CDK complex which has already begun to be produced in response to different signals

A

P21

24
Q

_____ viruses:

  • genome is ds circular molecule
  • Nonenveloped
  • at least 100 different types
  • cutaneous or mucosal
A

HPVs

25
Q

______-enlarged keratinocytes with clear halos around enlarged nuclei -characteristic of HPV infection

A

Koilocytes

26
Q

_____accesses basal layer through breaks in skinViral early genes stimulate cell growth (which facilitates viral replication)
- reproduction coordinated with development of keratinocytes

A

HPV

27
Q

As cells move through skin layers the gene expression and DNA replication begins (uses cellular DNA polymerase)
Late proteins (capsid proteins) only made in differentiated layers
Assembly occurs in nucleus during keratinocyte development
Nuclear remnant with viral particles shed at skin surface. They are not lytic.

A

HPV

28
Q

_______ are spread via:
breaks in skin for example, scratching
mucous membranes more susceptible
sexual contact During birth

A

HPV

29
Q

The following are found in _____: Warts of oropharynx laryngeal papillomas (-6 and -11)
respiratory papillomatosis hoarseness is usual symptom (signify obstructing HPV lesions)respiratory distress and secondary bacterial pneumonia in children

A

HPV

30
Q

________ are the most benign epithelial tumors of the oral cavity

A

Single oral papillomas

31
Q

What are the 2 types of HPV seen in cervical cancer?

A

16 and 18

32
Q

-___ is common in anogenital warts (condylomata acuminata) and cervical cancer

A

HPV

33
Q

____: cells are scraped from the cervix and examined under a microscope to check for disease or other problems; used to find HPV

A

Pap smear

34
Q

What 2 types of HPV are treated via vaccination?

A

16 and 18

35
Q

The HPV ___ and ______ proteins are important for cancer development. They are the only 2 HPV proteins always expressed in cervical cancer cells.

A

E6 and E7 proteins

36
Q

___ HPV protein inactivates p53 via ubiquitination promotion

A

E6

37
Q

___ HPV protein inactivates Rb; acts like SV40 virus

A

E7

Microbiology (46 decks)

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