Antigen Recognition in the Adaptive Immune System Flashcards
Which receptor dealing with adaptive immunity recognizes only proteins?
TCR
Which receptor dealing with adaptive immunity recognizes all macromolecules?
BCR
Which receptor dealing with adaptive immunity does not perform effector functions?
TCR
_____ are the 3 variable antigen-binding loops attached to BCR
Complementarity determining region (CDR) loops
The isotype of an antibody is determined by what portion of the antibody?
C region of heavy chain
Which 2 antibodies function as naive B cell antigen receptor?
IgD and IgM
Does class switching occur in constant regions or variable regions?
Constant regions
______: antibody recognizes more than one antigen
Cross-reactivity
______: portion of protein recognized and bound; has certain affinity
Epitope
What type of forces hold antibodies together?
Non-covalent forces (i.e. van Der Waals and electrostatic)
Which receptor dealing with adaptive immunity are all embedded in a membrane?
TCR
Which receptor dealing with adaptive immunity has more interactions involved for function?
TCR
The _____ region of TCR binds the molecule in antigen and recognizes the MHC molecule?
A-alpha region
Does an Ig or TCR have MHC dependence?
TCR
Which antigen-binding molecule of adaptive immunity has a higher affinity?
Ig
Which antigen-binding molecule of adaptive immunity has rapid on-rate and a variable off-rate?
Ig
Which antigen-binding molecule of adaptive immunity has slow on-rate and a slow off-rate?
TCR
IF there is a strong antigen recognition on an immature B/T cell, what is the outcome? (Neg or Pos selection)
Negative selection
IF there is a weak antigen recognition on an immature B/T cell, what is the outcome? (Neg or Pos selection)
Positive selection
The Enzyme mediating recombination to achieve diversity in antigen receptors is a lymphoid specific ______ plus repair enzymes to heal the double strand breaks created in the process.
recombinase
Does the heavy or light chain of antibody mature first?
Heavy chain
_____ chain recombination is the first to create pre-TCR
Beta
If there is weak reception of class 2 MHC + peptide, what cell is made?
Mature CD4+ cell
If there is weak reception of class 1 MHC + peptide, what cell is made?
Mature CD8+ cell
If there is no or strong reception of class 1 or class 2 MHC + peptide, what happens?
Apoptosis
