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Microbiology > Antigen Recognition in the Adaptive Immune System > Flashcards

Antigen Recognition in the Adaptive Immune System Flashcards

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1
Q

Which receptor dealing with adaptive immunity recognizes only proteins?

A

TCR

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2
Q

Which receptor dealing with adaptive immunity recognizes all macromolecules?

A

BCR

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3
Q

Which receptor dealing with adaptive immunity does not perform effector functions?

A

TCR

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4
Q

_____ are the 3 variable antigen-binding loops attached to BCR

A

Complementarity determining region (CDR) loops

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5
Q

The isotype of an antibody is determined by what portion of the antibody?

A

C region of heavy chain

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6
Q

Which 2 antibodies function as naive B cell antigen receptor?

A

IgD and IgM

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7
Q

Does class switching occur in constant regions or variable regions?

A

Constant regions

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8
Q

______: antibody recognizes more than one antigen

A

Cross-reactivity

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9
Q

______: portion of protein recognized and bound; has certain affinity

A

Epitope

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10
Q

What type of forces hold antibodies together?

A

Non-covalent forces (i.e. van Der Waals and electrostatic)

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11
Q

Which receptor dealing with adaptive immunity are all embedded in a membrane?

A

TCR

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12
Q

Which receptor dealing with adaptive immunity has more interactions involved for function?

A

TCR

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13
Q

The _____ region of TCR binds the molecule in antigen and recognizes the MHC molecule?

A

A-alpha region

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14
Q

Does an Ig or TCR have MHC dependence?

A

TCR

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15
Q

Which antigen-binding molecule of adaptive immunity has a higher affinity?

A

Ig

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16
Q

Which antigen-binding molecule of adaptive immunity has rapid on-rate and a variable off-rate?

A

Ig

17
Q

Which antigen-binding molecule of adaptive immunity has slow on-rate and a slow off-rate?

A

TCR

18
Q

IF there is a strong antigen recognition on an immature B/T cell, what is the outcome? (Neg or Pos selection)

A

Negative selection

19
Q

IF there is a weak antigen recognition on an immature B/T cell, what is the outcome? (Neg or Pos selection)

A

Positive selection

20
Q

The Enzyme mediating recombination to achieve diversity in antigen receptors is a lymphoid specific ______ plus repair enzymes to heal the double strand breaks created in the process.

A

recombinase

21
Q

Does the heavy or light chain of antibody mature first?

A

Heavy chain

22
Q

_____ chain recombination is the first to create pre-TCR

A

Beta

23
Q

If there is weak reception of class 2 MHC + peptide, what cell is made?

A

Mature CD4+ cell

24
Q

If there is weak reception of class 1 MHC + peptide, what cell is made?

A

Mature CD8+ cell

25
Q

If there is no or strong reception of class 1 or class 2 MHC + peptide, what happens?

A

Apoptosis

Microbiology (46 decks)

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