Humoral immunity

Question 1

Is a T-dependent B cell a follicular cell or a mucosal cell?

Answer 1

follicular

Question 2

Is a T-independent B cell a follicular cell or a mucosal cell?

Answer 2

mucosal

Question 3

isotype-switched, high affinity antibodies; memory B cell, long lived plamsa cells

Answer 3

T-dependent

Question 4

Mainly IgM, low affinity antibodies; short lived plasma cells.

Answer 4

T-independent

Question 5

What is the main switch from the primary antibody response to the secondary antibody response.

Answer 5

IgM to IgG

Question 6

Activated T cells that recognize antigen presented on B cells use_____ ligand and cytokines to activate the B cell and causes proliferation and differentiation.

Answer 6

CD40

Question 7

Previously formed VDJ exon recombines to become adjacent to a different constant region gene (than µ; IgM)

Answer 7

Switch recombination

Question 8

Repeated exposure to a _____ _____ drives creation of higher affinity antibodies

Answer 8

protein antigen

Question 9

activation-induced deaminase is involved; deaminates cytosine (DNA base) to uracil. Sometimes uracil is cleaved (see isotype switching) and repaired by an error-prone mechanism. Even when uracil persists, it results in a base pairing change.

Answer 9

Somatic Hypermutation AID

Question 10

______ present antigen via antibodies bound to Fc receptors or complement receptors instead of MHC molecules Antigens are never internalized by FDCs. (figure does not depict a surface bound antibody on FDC). The antibodies are those that were secreted by B cells themselves.

Answer 10

FDCs

Question 11

_____ response terminated once sufficient quantities of IgG are produced to result in this combination of binding on a B cell.

Answer 11

Humoral

Question 12

Neutralization of micrbos and toxins,

opsonization of antigens fro phagocytosis by macrophages and neutrophils

activation of the classical pathway of complement

antibody-dependent cellular cytotoxicity mediated by NK cells.

Neonatal immunity: transfer of maternal antibody across placenta and gut.

feedback inhibition of B cell activation

Answer 12

IgG effector mechanism

Question 13

activation of the classical pathway of complement

Answer 13

IgM effector mechanism

Question 14

mucosal immunity: secretion of IgA into lumens of gastrointestinal and respiratory tracts, neutralization of microbes and toxins

Answer 14

IgA Effector mechanism

Question 15

Eosinophil- and mast cell mediated defense against helminths

Answer 15

IgE effector mechanism

Question 16

t/f: the complement system is a component of the innate immune response.

Answer 16

true

Question 17

t/f: Classical pathway of the is part of Adaptive Immune Response.

Answer 17

true

Question 18

Classical pathway starts with recognition of antigen-engaged antibodies by complement ___ protein.

Answer 18

C1