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Microbiology > Helicobacter-Psuedomonas-Bordetella-Corynebacterium > Flashcards

Helicobacter-Psuedomonas-Bordetella-Corynebacterium Flashcards

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Biology 101 flashcards
1
Q

What shape and gram stain is helicobacter pylori?

A

Gram - vibrio

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2
Q 
The following are virulence factors of \_\_\_\_\_\_:
Urease
VacA
CagA
Mucinase
Flagella
A

Helicobacter pylori

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3
Q

____: protein acts on gastric mucosal epithelia and promotes flow of urea into stomach; virulence factor of Helicobacter pylori

A

VacA

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4
Q

_____ protein: injected into host epithelia cells change (prelude to cancer); virulence factor of Helicobacter pylori

A

CagA

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5
Q

_____: degrades mucus later for bacterial invasion;virulence factor of Helicobacter pylori

A

Mucinase

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6
Q

_____: (urea ->ammonia ->pH increase, neutralization of stomach acid); virulence factor of Helicobacter pylori

A

urease

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7
Q

Initial infection induces a low grade immune response with IgM, followed by IgA and IgG production.
This suppresses bacterial growth and leads to the typical low-level persistent infection which remains symptom-free for 80-90% of carriers

A

Gastric ulcer

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8
Q

For a _____, there is no proven preventative measure. Most infections cured by 2 antibiotics together plus a med to suppress stomach acid

A

Gastric ulcer

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9
Q

Organisms survive the acidity of stomach juices by producing a powerful ______

A

Urease

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10
Q

Upon reaching the later of mucus, the bacteria penetrate to the epithelial surface where bacterial products incite an ____ response

A

Inflammatory response

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11
Q

Once the mucus layer is thinned, between ____ and ____ % of infected individuals develop ulcers

A

10-20%

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12
Q

What bacteria is the most common associated bacteria with gastric ulcers?

A

Helicobacter pylori

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13
Q

Does H. pylori confer antibiotic resistance?

A

Yes

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14
Q

Are most people infected with H pylori symptomatic or asymptomatic?

A

Asympomatic

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15
Q 
Gram− short rods
polar flagella(one or more; high mobility)
obligate aerobe 
simple nutrient requirements (acetate)
broad temperature range: 20 to 43 ºC
A

Pseudomonas aeruginosa

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16
Q

What is the gram stain and shape of Pseudomonas aeruginosa?

A

Gram - rods

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17
Q

What is the O2 requirements of Pseudomonas aeruginosa?

A

Obligate aerobes

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18
Q 
The following virulence factors are characteristic of \_\_\_\_\_:
Pili
Flagellum
Siderophores
Pyocyanin
Exotoxin A
Alginate
Capsule
LPS
A

Pseudomonas aeruginosa

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19
Q

____ is a virulence factor of Pseudomonas aeruginosa used for adherence, protection from dehydration, and immune evasion; helps to form biofilm

A

Alginate

20
Q

____ is a virulence factor of Pseudomonas aeruginosa used for endotoxicity, core interacts with CFTR; protects from complement-mediated killing

A

LPS

21
Q

_____ is opportunistic pathogen(in case of disease, cancer, weakened immunity):
1.common in environment (water, soil)
+ Hot tubs are perfect culture conditions (due to heat tolerance)
2.resistance to many chemical desinfectants (like iodine)
3.R-plasmid based resistance to many antibiotics

A

Pseudomonas aeruginosa

22
Q

major problem in hospitals (nosocomial infections)

  • lungs: artificial ventilators, cystic fibrosis(mucoid strains)
  • skin: burn victims, folliculitis
  • bladder infections
  • ear infections (swimmer’s ear: otitis externa)
  • eye infections (from contact lenses)
A

Pseudomonas aeruginosa

23
Q

Soluble blue-green dye _____ and ______ characterize P.aeriginosa

A

pyocyanin and pyoverdin

24
Q

_____ is usually a nosocomial infection and clinically seen in pulmonary conditions like CF patients

A

Pseudomonas aeruginosa

25
Q

What is Bordetella pertussis gram stain and shape?

A

Gram - coccobacilli

26
Q

What is Bordetella pertussis O2 requirements

A

Strict aerobe

27
Q

Gram−coccobacilli
strict aerobe
non-motile, capsule

A

Bordetella pertussis

28
Q

________: Show dense surface growth in the lower respiratory tract (bronchi, bronchioli) without cell invasion and with strong mucus secretion.

A

Bordetella pertussis

29
Q

____ is highly contagious; causes whooping cough; childhood disease

A

Bordetella pertussis

30
Q

_____ is a condition characterized by adhesion to ciliated respiratory tract cells but NOT invasive

A

Whooping cough(pertussis)

31
Q

The following virulence factors are associated with _________:
Pertussis toxin ptx
secreted invasive adenylate cyclase / hemolysin
Tracheal cytotoxin

A

Bordetella pertussis

32
Q

____ is a virulence factor of Bordetella pertussis:

ADP-ribosylation of G-protein: cAMP­mucus­and other secretions

A

pertussis toxin ptx

33
Q

____ is a virulence factor of Bordetella pertussis:

increases cAMP­

A

secreted invasive adenylate cyclase / hemolysin

34
Q

____ is a virulence factor of Bordetella pertussis:
(Nitric Oxide NOrelease) kills ciliated cells
toxin is a component of peptidoglycan disaccharride-tetrapeptide

A

Tracheal cytotoxin

35
Q

Most gram negative bacteria keep ____ within the cell wall by using a transporter protein to recycle it. (Bordetella pertussis)

A

TCT

36
Q

_____ not capable of recycling TCT and it escapes to the surrounding environment.

A

B. pertussis

37
Q

_____ is treated via the DTAP vaccine; transmitted via aerosol; children’s disease

A

Bordetella pertussis

38
Q

What is the gram stain and shape of Corynebacterium diphtheriae?

A

Gram+pleiomorphic (club-shaped) rods

39
Q

Gram+pleomorphic (club-shaped)rods
facultative anaerobe
opportunistic pathogen
oral pathogen with systemic effects

A

Corynebacterium diphtheriae

40
Q

What disease does Corynebacterium diphtheriae cause?

A

Diphtheria

41
Q

_____ is characteristics include pseudomembrane in the throat; heart, kidney damage (Corynebacterium diphtheriae)

A

Diphtheria

42
Q

_____- inhibits protein synthesis by inactivating an elongation factor of eukaryotic cells. Kills local cells in the throat but can also by carried in the blood stream to various organs

A

Diphtheria

43
Q

Virulence Factors of Corynebacterium diphtheriae: throat adhesion ____________: (ADP-ribosylationof EF-2 causing translation stop)
cell death -> pseudomembrane
Pseudomembrane= C.diphtheriae cells + damaged host cells + blood
-Block air passage

A

diphtheria toxin

44
Q 
\_\_\_\_\_\_ (Corynebacterium diphtheriae)
•paralysis 
-impaired swallowing peripheral neuritis
•Suffocation (due to blockage)systemic:
•cardiac arrhythmia
•kidney failure
A

Diphtheria toxins

45
Q

______ is spread via saliva droplets; prevented by toxoid vaccination

A

Diphtheria toxin

Microbiology (46 decks)

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