SCHIZOPHRENIA : BIO EXPLA - genetic basis of schizo

Question 1

FAMILY STUDIES - What have they confirmed

Answer 1

risk of schizo increases in line with genetic similarity to a relative with the disorder

Question 2

FAMILY STUDIES - what does irving gottesman large scale 1991 fmaily study show

Answer 2

as you move down degrees of relative (3rd - first cousins , 2nd - grandchildren 1st -children to identical twins )

risk of developing schizo icnreases

Question 3

FAMILY STUDIES - give example of irving study

Answer 3

someone with aunt has 2% chance of develping schizo

increases to 9% if indidvidual is/has a sibling with it

48% if their an indentical twin

Question 4

FAMILY STUDIES - what two things do fmaily members tend to share

Answer 4

aspects of enviro as well as many genes

Question 5

FAMILY STUDIES - as fmily members tend to share aspects of enviro + genes correlation

Answer 5

represents both

Question 6

FAMILY STUDIES - eventhough correlation represents both aspects of enviro + genes family share family studies still

Answer 6

give good support for improtance of genes in schizo

Question 7

CANDIDATE GENES - What are they

Answer 7

gene believed to be related to particular trait, such as a disease or a physical attribute

Question 8

CANDIDATE GENES - early research concerning candidate genes looked for..

Answer 8

a single genetic variation in belief that one faulty gene could explain schizo

Question 9

CANDIDATE GENES - early research looked for a single genetic variation in belief one faulty gene could xplain schizo however it appears

Answer 9

number of diffreent genes are involved

Question 10

CANDIDATE GENES - as number of differnet genes invovled in developmetn of schizo phrebia its described as

Answer 10

polygenic

Question 11

CANDIDATE GENES - hay a number of different genes involved in development of shizophrenia. : the most likely genes invoved would be those coding for …

Answer 11

neurotransmitters including dopamine

Question 12

CANDIDATE GENES - what did ripke et al do in his study 2014

Answer 12

combiend all rpevious data from genome wide studies ( i.e those lookign at whole human genomes as opposed to particular genes) of schizo

genetic makeup of 37k people with schizo diagno copmared to that of 113k controls

Question 13

CANDIDATE GENES - What were the results of ripke et al study

Answer 13

108 seperate genetic variations associated with slightly increased risk of schizo

Question 14

CANDIDATE GENES - because different studies have identified different canidate gene sit appears schizo is also

Answer 14

aetiologically heterogeneous

Question 15

CANDIDATE GENES - ehat does aetiologically heterogeneous mean

Answer 15

diffrerent combo of factors including genetic variation can lead to schizo

Question 16

CANDIDATE GENES - ehat does aetiologically heterogeneous mean

Answer 16

diffrerent combo of factors including genetic variation can lead to schizo

Question 17

ROLE OF MUTATION - schizo can also have what type of origin

Answer 17

genetic origin

Question 18

ROLE OF MUTATION - when can schizo have a genetic orgin

Answer 18

in absence of family hstory of disorder

Question 19

ROLE OF MUTATION - one explanatio for the mutation iin …

Answer 19

parental dna

Question 20

ROLE OF MUTATION - the mutation in parental dna can be caused by

Answer 20

radiation , poison , viral infection

Question 21

ROLE OF MUTATION - where does evidence for mutation come from

Answer 21

positive correlations between paternal age