module 9 disorders of skeletal muscles, peds, aging Flashcards
contracture
muscle fiber shortening without an action potential
- cause by failure of the sarcoplasmic reticulum (calcium pump) even with available ATP; lack of use
stress induced muscle tension
neck stiffness back pain clenching teeth hand grip headache -associated with chronic anxiety - work demands
fibromyalgia
muscle pain target points - occiput - trapezius - suprasinatus - gluteal - greater trochanter - anterior neck - second rib - lateral epicondyle - knee fatigue sleep disturbance increased stimulus to touch
disuse atrophy
reduction in normal size of muscle cells due to prolonged inactivity
- bed rest
- trauma
- casting
- nerve damage
disuse atrophy tx
isometric movement ans passive lengthening exercises
diseases of energy metabolism
McArdle disease - myophysphorylase dificiency Acid Maltase deficiency - Pompe disease Myoadenylate deaminase deficiency (MDD) Lipid Deficiencies
Inflammatory muscle disease (dermatomyositis, polymyositis)
Focal or extensive degeneration fo muscle fibers attributable to inflammation infiltrates of lymphocytes, macrophages
- inflammatory cytokines, autoantibodies, cytotoxic
-> necrosis of muscle fibers -> fatty replacement -> weakness
collectively: myositis
viral, bacterial, and parasitic myositis
- staphylococcus aureus
- trichinosis
- toxoplasmosis
inflammatory muscle disease (myositis) s/s
weakness in proximal limb muscles
esophageal dysmotility can be seen
dermatomyositis
gottron papules: flat top over dorsal surface of hand joints
scaly patches over joints
rashes
Duchenne Muscular Dystrophy
most common muscular dystrophy
X-linked recessive inheritance: Mostly males affected
- deletion of segment of DNA on short arm of the X
Duchene muscular dystrophy gene
- encodes for dystrophin protein (deficient)
– mediates the anchorage of the actin cytoskeleton of the skeletal muscle fiber to the basement membrane -> wasting of skeletal muscle
Duchenne muscular dystrophy s/s
shoulders and arms held back when walking
sway back
weak butt muscles
knees bend to take wt
thick lower leg muscles (mostly fat, not strong)
tight heel cord -> toe walking
weak muscles in front of leg -> foot drop
belly sticks out due to weak abd. muscles
thin weak thighs
poor balance -> falls often, clumsy
decreased dystrophin -> weakened cell membrane -> extracellular fluid leaks into cell -> muscle fiber necrosis
Dechenne muscular dystrophy tx
education
preservation of physical function as long as possible
prevent contractures
genu varum
bowleg
peaks at 2.5 years
occurs in all newborns due to intrauterine stress
pathogenic past 2.5 years
genu valgum
knock-knees
peaks at 5-6 years
pathologic past 5-6 years
congenital defects
syndactyly: webbing or fusion of fingers vestigial tabs: extra digits deformities of foot: - metatarsus adductus (forefoot adduction ) - equinovarus deformity (club foot)
developmental dysplasia of the hip
abnormality of the proximal femur, acetabulum, or both
risk factors (head of femur in pelvis)
- female, metatarsus addutus, torticollis, oligohydramnios, 1st pregnancy, breech
