module 12 beta-lactams cephalosporins

Question 1

1st generation Rx

Answer 1

cephalexin

cefazolin

Question 2

1st generation spectrum of activity

Answer 2

gram +
- MSSA
- Strep
limited gram -
- H. influenzae
- E. coli
- K. pneumoniae

Question 3

2nd generation Rx

Answer 3

cefuroxime
cefoxitin
cefotetan

Question 4

2nd generation spectrum of activity

Answer 4

cefuroxime:
- gram +: MSSA, strep
- gram -: H. influenzae, E.coli, K. pneumoniae, M. catarrhalis
Cefoxitin, Cefotetan:
- dec. MSSA activity
- inc. gram - activity
- gram - anaerobes

Question 5

3rd generation Rx

Answer 5

ceftazidime
ceftriaxone
cefotaxime

Question 6

3rd Gen ceftazidime spectrum of action

Answer 6

psudomanas

excellent gram -

Question 7

3rd gen ceftriaxone spectrum of action

Answer 7

very good gram - aerobes

moderate gram + aerobes

Question 8

4th generaction Rx

Answer 8

cefepime

Question 9

cefepime spectrum of action

Answer 9

moderate gram +
excellent gram -
psudomonas
poor anaerobic coverage

Question 10

5th generation Rx

Answer 10

Ceftaroline

Question 11

ceftaroline spectrum of action

Answer 11

Gram +
- only b-lactam against MRSA
- s. pneumoniae 
Gram -
- H. influenza, k. pneumoniae, E. coli
enderobacteriacasae
- not ESBL-production 
no nonfermentative gram - activity

Question 12

cephalosporine with good CSF penetration

Answer 12

ceftriaxone
cefotaxime
cefepime

Question 13

cephalosporin administration

Answer 13

bactericidal

Question 14

cephalosporin education

Answer 14

possible cross reactivity

Question 15

cephalosporin precaution

Answer 15

renal dysfunction -> dose adjustment

- not needed with ceftriaxone