module 12 protein synthesis inhibitors

Question 1

tetracycline Rx

Answer 1

doxycycline
minocycline
tetracycline

Question 2

tetracycline MOA

Answer 2

binds to 30S ribosomal subunit

-> inhibits protein synthesis

Question 3

tetracycline spectrum of activity

Answer 3

gram + and -
no pseudomonas
good with atypical pathogens

Question 4

tetracycline administration

Answer 4

bacteriostatic

PO: dec. absorption with antacids, sucralfate

Question 5

tetracycline AE

Answer 5

Gi upset
phototoxicity
teeth discoloration
minocycline: vestibular disturbance

Question 6

tigecycline MOA

Answer 6

class: glycylcycline
binds to 30S ribosomal subunit
-> inhibit protein synthesis

Question 7

tigecycline spectrum of activity

Answer 7

gram +
- MSSA
- MRSA
- enterococcus
- streptococcus
gram -
- E.coli, klebsiella, enterobacter, acintobacter
- citrobacter, H. flu, M. catarrhalis, neisseria
- salmonella, shigella 
Not effective: 
- psudeomonas
- proteius, B. capacia, S.maltophilla, legionella

Question 8

tigecycline AE

Answer 8

N/V

hypotension

Question 9

tigacycline administration

Answer 9

bacteriostatic

IV only

Question 10

tigacycline education

Answer 10

take with antiemetic

Question 11

tigacycline use

Answer 11

complicated skin and soft tissue infection

complicated intra-abd. infection

Question 12

macrolides Rx

Answer 12

erythromycin
clarithromycin
azithromycin

Question 13

macrolide MOA

Answer 13

bind 50S ribosomal subunit
-> inhibit protein syntheis
blocks translocation of peptides form A to P site

Question 14

macrolide spectrum of activity

Answer 14

gram + and -
no gram - anaerobes
good with atypical pathogens

Question 15

macrolide AE

Answer 15

GI effects: worse with erythomycin

azithro: QT prolongation

Question 16

macrolide DI

Answer 16

CYP450

- warfarin, phenytoin (less with azithro)

Question 17

clindamycin MOA

Answer 17

class: lincosamide
binds to 50S ribosomal subunit
-> inhibit protein synthsis
inhibits peptidyl transferase

Question 18

clindamycin spectrum of activity

Answer 18

gram +
gram - anaerobes
toxoplasmosis gondii
no gram - aerobic

Question 19

clindamycin use

Answer 19

above diaphragm aspiration

cellulitis: pt w/ penicillin allergy

Question 20

clindamycin administration

Answer 20

bacteriostatic

PO dose dec. from IV d/t GI AE

Question 21

clindamycin AE

Answer 21

GI upset

blood dyscrasias

Question 22

clindamycin precaution

Answer 22

hepatically metabolized

Question 23

clindamycin DI

Answer 23

macrolides