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Pathophysiology > module 12 cell membrane acting agents > Flashcards

module 12 cell membrane acting agents Flashcards

1
Q

daptomycin MOA

A

binds to components of cell membrane

-> rapid depolarization, inhibiting synthesis of DNA, RNA, and proteins

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2
Q

daptomycin spectrum of activity

A

gram +

-inc: staph, strep, VRE, MRSA, VISA/VRSA

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3
Q

daptomycin AE

A

muscle pain
HA
GI upset
insomnia

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4
Q

daptomycin administration

A

bactericidal

  • concentration dependent
    wt. based dosing
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5
Q

daptomycin monitoring

A

CPK: baseline and weekly

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6
Q

daptomycin education

A

ineffective against pulmonary infections

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7
Q

polymixins Rx

A

polymixin E

polymixin B

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8
Q

polymixin MOA

A

detergent like
interacts with lipopolysaccharides in outer membrane
-> inc permeability and damage
-> inc. susceptibility to hydrophilic abx

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9
Q

polymixin administration

A

bactericidal
- concentration dependent
polymixin E: eliminated non-renally
polymixin B: active drug

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Pathophysiology (80 decks)

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