module 12 other cell wall-acting agents

Question 1

monobactam Rx

Answer 1

aztreonam

Question 2

aztreonam MOA

Answer 2

inhibit cell wall synthesis

- binds to PBP-3 in gram - bacteria

Question 3

aztreonam spectrum of activity

Answer 3

gram - including: pseudomonas aeruginosa

Question 4

aztreonam uses

Answer 4

good substitute for pt with penicillin allergy or inc. risk of aminoglycoside toxicity

Question 5

glycopeptides MOA

Answer 5

inhibit cell wall synthesis

• binds to D-alanyl-D-alanine precursor in gram + bacteria
• > no peptidoglycan cross linking

Question 6

vancomycin spectrum of activity

Answer 6

gram + only

• MRSA
• enterococcus
• coagulase - neg. staph
• oral: c. diff

Question 7

vancomycin precaution

Answer 7

dose adjust with renal insufficiency

Question 8

vancomycin AE

Answer 8

red mans syndrome: related to infusion

rare: nephrotoxicity, ototoxicity

Question 9

vancomycin monitoring

Answer 9

drug level: trough

Question 10

glycopeptide Rx

Answer 10

vancomycin
televancin
dalbavancin
oritavancin

Question 11

televancin, dalbavancin, oritavancin spectrum of activity

Answer 11

Gram + only

- staph, strep, enterococcus

Question 12

televancin, dalbavancin, oritavancin education

Answer 12

less monitoring than vanco

simplified dosing