module 10 congenital heart defects Flashcards
circulation in utero
fetal pulmonary vascular resistance HIGH
systemic resistance low
placenta is the site of gas exchange
Birth and circulation
gas exchange shifts to lungs pulmonary resistance decreases systemic resistance increases Closure of foramen ovale: 1st month Closure of ductus arteriosis: 10-21 days
foramen ovale
opening between RA and LA
ductus arteriosus
connects pulmonary artery and aorta
congenital heart defects
may be attributed to
- maternal rubella during first trimester
- exposure to cardiac teratogens
- genetic influences
result in 2 primary pathologic processes
- shunting of blood through abnml pathways
- obstruction of blood flow d/t narrowing
shunting of blood
left to right: acyanotic -> inc. workload on R. side of heart -> RV hypertrophy -> inc. Right sided pressure --- possible switching to a right to left shunt right to left: cyanotic
obstructive
stenosis or atresia: failure of valves to develop
coarctation of aorta: narrowing
acyanotic congenital defects
desorders that result in left to right shunting
- atrial septal defect
- ventricular septal defect
- patent ductus arteriosus
- coarctation of the aorta
- pulmonary and aortic stenosis or atresia
ASD atrial septal defect
foramen ovale did not close -> inc. pulmonary blood flow -> inc. right side hypertrophy small defects may be asymptomatic for years long term: - pulmonary HTN - RV hypertrophy - possible reversal of shunt to a right to left pattern
VSD ventricular septal defect
commonly associated w/ other cardiac defects
initially left to right w/ inc. pulmonary flow
-> RV hypertrophy -> reversal of shunt
systolic murmur
PDA patent ductus arteriosis
ductus arteriosis does not close nml closure 1-2 days after birth -blood from aorta -> pulmonary artery - can close spontaneously -- prostaglandin inhibitors can induce closure - harsh systolic murmur - systolic thrill - can lead to pulmonary hyperTN -> RSHF -> reversal of shunt
COA coarctation of the aorta
narrowing of the aorta
rarely happens by self
males > females 3-4x
can occur anywhere in aorta but usually close to ductus arteriosus
- preductal: more severe
-> lower blood flow maintained by ductus arteriosus -> RSHF
- postductal: less severe
Upper extremity: Inc. BP
Lower extremity: Dec. BP and weak pulses
systolic murmur
ventricular hypertrophy
pulmonary stenosis/atresia
No communication between RV and lungs
- blood must go through septal opening then through ductus arterisosus
- RV hypoplasia
- ASD large
- mild-severe: depends on narrowing of pulmonic valve
- RV hypertrophy secondary to high afterload caused by narrow opening
Aortic stenosis/ atresia
rare not compatible with life correctable with good prognosis Inc. LV afterload r/t small opening systolic murmur
cyanotic congenital defects
result in right to left shunting
- Tetralogy of Fallot
- transposition of great arteries
- truncus arteriosus
- tricuspid atresia