module 12 beta-lactams carbapenems

Question 1

carbapenem drugs

Answer 1

imipenem/cilastatin
meropenem
ertapenem

Question 2

carbapenem MOA

Answer 2

inhibit cell wall synthesis
contain fused B-lactam ring and 5-member ring system
- resistant to B-lactamases

Question 3

carbapenem AE

Answer 3

dec. seizure threshold

- imipenem worst

Question 4

carbapenem precaution

Answer 4

adjust dose w/ renal dysfunction

Question 5

entapenem administration

Answer 5

daily dosing d/t long half life

Question 6

carbapenems education

Answer 6

resistancy d/t carbapenamases
-> can lead to toxicity
cross-reactivity with penicillins

Question 7

imipenem and peropenum spectrum of activity

Answer 7

gram + except MRSA, VRE
Excellent gram - including: P. aeruginosa
excellent anaerobes
no listeria

Question 8

entapenem spectrum of activity

Answer 8

excellect anaerobes
moderate gram -
poor: psudeomonas, acinetobacter
not for hospital acquired infections