module 12 protein inhibitors: aminoglycosides, oxalodidinones Flashcards
aminoglycosides Rx
gentamicin
tobramicin
amikacin
streptomycin
aminoglycosides MOA
bind irreversibly to 30S ribosome subunit
-> inhibits protein synthesis
blocks initiation of protein synthesis
interferes with proofreading
aminoglycosides spectrum of activity
gram - aerobic
- including: pseudomonas aeruginosa
aminoglycosides administration
rapidly bactericidal
- concentration dependent: inc. conc. w/out AE: best reult
- extended-interval dosing
aminoglycosides AE
nephrotoxicity
ototoxicity
aminoglycosides monitoring
serum creatinine
aminoglycosides education
post antibiotic effect: residual bactericidal activity
oxalodidinones Rx
linezolid
tedizolid
oxalodidinones MOA
binds to 23S and 50S ribosomal subunits
- > inhibits protein synthesis
- > prevents 70S complex that is vital for translation process
oxalodidnones spectrum of activity
gram + aerobes
oxalodidnones administration
bacteriostatic:
- enterococci
- staphylococci
bacteriocidal:
- streptococci
oxalodidnones DI
MAOI: additive serotonin effect
- antipsychotics/depressants
