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Pathophysiology > module 12 sulfonamides and UTI meds > Flashcards

module 12 sulfonamides and UTI meds Flashcards

1
Q

sulfonamide Rx

A

sulfamethoxazole

sulfadiazine

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2
Q

sulfonamides MOA

A

mimics PABA and inhibits bacterial biosynthesis of folic acid

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3
Q

sulfonamides uses

A 
otitis media
meningitis
UTI
toxoplasmosis
PCP
URI
stentrophomonas maltophilia
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4
Q

sulfonamides AE

A 
hypersensitivity
hemolytic anemia
megaloblastic anemia
neutropenia
agranulocytosis
crystalluria
hematuria
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5
Q

sulfonamides administration

A

bacteriostatic

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6
Q

sulfonamides education

A

inc. fluids

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7
Q

sulfonamides DI

A

PABP compounds: procaine: mimics
potentiate: warfarin, sulfonylureas, phenytoin
bactrim inhibits 2C9
cross sensitivity with: thiazides, furosemide, sulfas

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8
Q

trimethoprim MOA

A

inhibits dihydrofolate reductase

-> dec. folic acid synthesis

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9
Q

trimethoprim use

A

alone: w/ sulfonamide allergy

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10
Q

trimethoprim administration

A

in combo with sulfamethoxazole

  • synergistic
  • dec. resistance
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11
Q

dapsone MOA

A

sulfone

mimic PABA and inhibit bacterial biosynthesis of folic acid

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12
Q

dapsone AE

A 
hemolytic anemia
leukopenia
methemoglobinemia
anorexia
N/V
HA
dizzy
lethargy 
psychosis 
mononucleosis-like syndrome
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13
Q

dapsone monitoring

A

G6PD: deficient -> inc. AE

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14
Q

dapsone education

A

more toxic than sulfonamides

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15
Q

phenazopyridine use

A

UTI
no antibacterial activity
for symptomatic relief

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16
Q

phenzopyridine administration

A

given in combo with sulfonamides

17
Q

phenazopyridine education

A

discoloration of the urine

local anesthetic action on urinary tract

18
Q

nitrofurantoin MOA

A

inhibits bacterial enzymes needed for protein, DNA, RNA, and cell wall synthesis

19
Q

nitrofurantoin use

A

UTI

20
Q

nitrofurantoin AE

A 
GI distress 
HSR
HA
vertigo/dizzy
polyneuropathy
altered urine color
21
Q

nitrofurantoin CI

A

renal dysfunction

22
Q

nitrofurantoin administration

A

bacteriocidal in urine

Pathophysiology (80 decks)

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