module 12 beta-lactams penicillin Flashcards

1
Q

beta lactam 3 drug classes

A

penicillins
cephalosporins
carapenems

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2
Q

beta lactam MOA

A

inhibit cell wall synthesis

  • bind to PBP -> inihibit transpeptidase
  • > inhibition of cell wall synthesis
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3
Q

beta lactam AE

A

hypersensitivity

  • severe: anaphylaxis
  • other: hives, rash
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4
Q

beta lactam administration

A

bacteriocidal

time dependent

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5
Q

beta lactam precaution

A

renally eliminated

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6
Q

beta lactam education

A

resistance d/t b-lactamase

cross-reactivity possible

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7
Q

naturally occurring penicillins

A

penicillin G
penicillin G benzathine
penicillin G procaine
penicillin V

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8
Q

PCNase resistant penicillins

A

nafcillin
oxacillin
dicloxacillin

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9
Q

amino penicillins

A

ampicillin
ampicillin/sulbactam
amoxicillin
amoxicillin/cluvalanate

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10
Q

extended spectrum penicillins

A

piperacillin
piperacillin/tazobactam
ticarcillin
ticarcillin/clavulanate

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11
Q

PBP

A

penicillin binding proteins

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12
Q

Penicillin G/V use

A
gram +
- strepococci
gram -
- neisseria
spirochetes
- T. pallidum 
cellulitis
otitis media
syphilis
strep
pneumococcal pneumonia
gangrene
oral abscess
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13
Q

B-lactamse resistant penicillins

A

cloxacillin
dicloxacillin
nafcillin
oxacillin

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14
Q

B-lactamase resistant penicillin spectrum of activity

A

gram +
- streptococci
- staphylococci
No enterococcus or gram - activity

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15
Q

B-lactamase side group

A

large side group prevents b-lactamase from cleaving B-lactam ring

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16
Q

aminopenicillin use

A
streptococcus
enterococcus
listeria
inc. anaerobe coverage 
gram -
- E. coli
- H. influenza
- K. pneumoniae
17
Q

ampicillin/amoxicillin AE

A

hypersensitivity
GI effects
rare hematological AE
nonimmunologicial rash (MONO)

18
Q

extended spectrum penicillins spectrum of activity

A

gram +
excellent gram - including pseudomonas aeruginosa
anaerobes
Do not cover atypical organisms

19
Q

broadest spectrum among penicillins

A

pip/tazo (zosyn)