Hormone replacement treatment for lactation, pregnancy and delivery TEST #3 Flashcards
T/F Natural estrogens are not considered steroid hormones because they are natural
False
-They are steroid hormones
T/F Synthesized estrogens may be non-steroidal or steroidal
True
What are the stages of the menstrual cycle?
- Menstrual stage
- Follicular stage
- Luteal stage
T/F As populations age, they spend more time in menopause and andropause
True
What are three natural estrogens?
- Estrone E1
- Estradiol E2
- Estratriol E3
What natural estrogen is predominant during menopause?
E1 Estrone
What natural estrogen is predominant during productive years?
E2 Estradiol
What natural estrogen is predominant during pregnancy?
-E3 Estratriol
What are Synthetic estrogens?
- Ethinyl estradiol
- Diethylstilbesterol
Which synthetic estrogen is non-steroidal?
-Diethylstilbesterol
Which synthetic estrogen is steroidal?
-Ethinyl estradiol
What are the physiological functions of Estrogen?
- Sexual maturity
- Increased CNS excitability
- Increased endometrial and uterine growth
- Maintain skin elasticity
- Reduce bone adsorption
- Increase blood coagulability
- Alters plasma lipids-increases HDL and TGC and reduces LDL
What are the main clinical uses for estrogen?
- Treat primary hypogonadism
- Postmenopausal problems
What are the guidelines for use with estrogen?
- Always use the smallest dose for the shortest period of time possible
- Sometimes local creams are preferred to minimize exposure
What are the adverse effects of estrogens?
- Postmenopausal bleeding
- Nausea
- Breast tenderness
- Migraines
- Hypertension
- Hyperpigmentation
- Increase some cancers
When is the use of estrogens contraindicated?
- Liver disease (slows metabolism)
- Breast/endometrial cancers
- Thrombolytic disorders
What are progestins mad from?
-Cholesterol
T/F Progestins are found in both males and females
True
What is the most important progestin in humans?
-Progesterone
What is progesterone a precurosr to?
- Estrogen
- Androgen
- Adrenocortical steroids such as Cortisol
- Testosterone
- Estradiol