Psychopath lecture 3 Flashcards
In stress what happens to the sympathetic activity?
-Increased
What are the normal types of anxiety disorders?
-Chronic, mild anxiety
What are the symptoms of chronic mild anxiety?
- Tense
- Irritable
What is the treatment for chronic mild anxiety?
-Do things that help you relax
If you have chronic moderately sever anxiety how long has it been going on for?
-Longer than 6 months
What are the symptoms for chronic moderately severe anxiety?
- Poor concentration
- No obvious reason
What are the treatment options for chronic moderately sever anxiety?
-Use anxiolytics/sedatives
What are the typical drugs used for anxiety?
-Benzodiazepines
What do Benzodiazepines act on?
-Agonists for BDZ receptors (decrease activity)
What does an agonist on BDZ receptors do?
-It is an allosteric modulator of GABA A receptors
What type of effect does Benzodiazepines have respiration?
-Has Little effect
What are the most popular CNS depressants?
-Benzodiazepines
What are the therapeutic action of Benzodiazepines?
- Anxiolytics
- Treat seizures
- Alcohol withdrawal
- Insomnia (hypnotic short acting)
- Muscle relaxation
- Often used a couple hours before surgical dental procedures
What are the adverse effects of Benzodiazepines?
- Tolerance
- Can cause addiction and withdrawal
- Interacts synergistically with other depressants
- Drowsiness
- Motor impairment
- Don’t use in a pt with major depression
- Decrease cognition
What are the two sedative benzodiazepines?
- Diazepam (Valium)
- Alprazolam (Xanax)
What is the half life of Diazepam (Valium)?
-20-100 hrs
What is the half life of Alprazolam (Xanax)?
-6-12 hrs
What are the two hypnotic benzodiazepines?
- Lorazepam (Ativan)
- Triazolam (Halcion)
What is the half life of Triazolam?
- 2 hrs
What is the half life of Lorazepam?
-6 hrs
What is a benzo like sleep aid?
-Zolpidem (Ambien)
What is the half life of zolpidem (Ambien)?
-2 hrs
What do Barbiturates do?
-Enhance GABA
What is a barbiturate that is used for short term anesthesia?
-Pentobarbital
