Anesthesia lecture 2 Flashcards
How are most modern inhaled anesthetics eliminated?
-Ventilation not metabolism
What type of pts should you not use halothane in?
-Pts with liver damage
What can prolonged exposure to nitrous oxide damage?
-Bone marrow
What type of toxicity do you see with prolonged exposure nitrous oxide?
- Hematotoxicity
- Mutagenicity
What are the features of non-opioid anesthetics?
- Lipophilic
- Rapid onset
- Termination by redistribution to fat/muscle tissue
T/F Non-opioid drugs does not provide complete anesthesia
True
What did propofol replace?
-Barbiturates
What does propofol do to respiration?
-Depresses it
What does propofol do to GABA?
-Increases GABA activity
What type of duration does propofol have?
-Short duration
How much time does it take propofol to metabolize (Redistribute)?
3-8 minutes
T/F Propofol is an analgesic not a hypnotic
False
-Propofol is hypnotic not analgesic
What is a short-acting barbiturate that is no longer available due to use in capital punishment?
-Thiopental
Does thiopental have analgesia effects?
-No
What does thiopental do to respiration?
-Reduced it
What type of induction does thiopental have?
-Rapid induction
What can barbiturates do to Blood pressure?
-Reduce it
What type of drug is Midazolam?
-Benzodiazapene
What type of drug is lorazepam?
-Benzodiazapene
What type of drug is diazepam?
-Benzodiazepene
What are the therapeutic uses of BDZs?
- Pre-operative (oral)
- IV sedation
- Good amnestic
- Not good analgesic
Is ketamine a good analgesic?
-Yes
Where does ketamine work at?
-NMDA (antagonist) and some DAT inhibition
What type of onset does ketamine have?
-Rapid
