Anticoagulants

Question 1

What pathway is sensitive to heparin?

Answer 1

-Intrinsic

Question 2

What are the side effects of Heparin?

Answer 2

• Hemorrhage
• Allergic reactions
• Osteoporosis
• Bone fractures

Question 3

What is a heparin like drugs that is frequently used?

Answer 3

-Enoxaparin (Lovenox)

Question 4

What is an indirect thrombin inhibitor?

Answer 4

-Heparin (effect is through antithrombin)

Question 5

What is an antidote for heparin?

Answer 5

-Protamine

Question 6

What pathway is sensitive to warfarin (Coumadin)?

Answer 6

-Extrinsic

Question 7

What are the side effects of Warfarin?

Answer 7

• Hemorrhage
• Numbness
• Pain
• Headache
• Dizziness

Question 8

What drug antagonizes vitamin K?

Answer 8

-Warfarin (Coumadin)

Question 9

Is heparin or warfarin a large molecule?

Answer 9

-Heparin (Warfarin is small)

Question 10

What is an alternative drugs for warfarin?

Answer 10

-Dabigatran (Pradaxa)

Question 11

What does Dabigatran (Pradaxa) affect?

Answer 11

-PTT (Intrinsic) pathway

Question 12

What does Rivaroxaban (Xarelto) do?

Answer 12

-It is an oral Xa factor inhibitor

Question 13

What are thrombolytic agents?

Answer 13

• Streptokinase

- Alteplase (Activase)

Question 14

What are anti-platelet agents?

Answer 14

• Aspirin
• Abciximab
• Plavix (clopidogrel)
• Cilostazol (Pletal)

Question 15

What is a glycoprotein inhibitor?

Answer 15

-Abciximab

Question 16

What is Abcisimab used for?

Answer 16

-To prevent clot formation as in unstable angina

Question 17

What is Bivalirudin?

Answer 17

Thrombin inhibitor

Question 18

What does Bivalirudin do?

Answer 18

-Short acting and inhibits circulating thrombin

Question 19

Rivaroxaban (Xarelto) has what type of onset and is the 1/2 life shorter or longer than warfarin?

Answer 19

• Rapid onset

- Shorter

Question 20

What does Streptokinase do?

Answer 20

-Recanalize the occluded coronary by dissolving clot