biologica treatments of schizophrenia ao1

Question 1

what drugs are used to treat schiz

Answer 1

antipsychotics

Question 2

all antipsychotics work as …

Answer 2

dopamine antagonists
they reduce the action of dopamine inareas of the brain assoiciated with symptos of schizophrenia

Question 3

2 types of antipsychotics

Answer 3

Typical
Atypical

Question 4

Typical antipsychotic is

Answer 4

Bind to dopamine receptors without stimulating them

Question 5

Atypical antipsychotics work by …

Answer 5

Drugs targeting 3 receptors
- dopamine receptors
- serotonin receptors
- glutamate receptors
They only temp occupy DA receptors before rapidly dissociating and allowing normal dopamine transmission

Question 6

Which is cheaper atypical or typical

Answer 6

Typical

Question 7

How does phenothiazine help - typical antipsychotic

Answer 7

Blocking dopamine receptors
Bind to them and stop action of da
Reduce positive symptoms in 60% of patients

Question 8

Problems with phenothiazine’s (3 issues and brief explanation)

Answer 8

Parkinson’s symptoms - muscle tremor
Neuroleptic malignant syndrome - muscle rigidnesss and impairment of autonomic nervous system
Tarditive dyslexia - Involuntary lip smacking

Question 9

1) Is Clozapine is atypical or typical
2) is chlorpromazine typical or atypical

Answer 9

1) Atypical - clozapine
2) typical - chlorpromazine

Question 10

Describe clozapine

Answer 10

Newer drug works on both serotonin and dopamine receptors
Usfuel for 85 percent of patients
Reduces both pos and neg symptoms

Question 11

How does clozapine work

Answer 11

Improve mood and reduce depression and anxiety
improves cognitive functioning

Question 12

Cloazipine prescribed when…

Answer 12

Patient at high risk of suicide
Important be around 30-50% patients attempt succide at an point

Question 13

Issues with clozapine

Answer 13

Patient has 1percent risk of developing agranulocytosis - causes WBC count to drop
Also more expensive so less widely available

Question 14

Typical antipsychotics reduce..

Answer 14

Postive symptoms

Question 15

Who did research into typical antipsychotics

Answer 15

Kapur et al 2000

Question 16

What did kapur et al 2000 find regarding typical antipsychotics

Answer 16

Between 60% and 70% of D2 receptors in the Mesolimblic pathway must be blocked in order for these drugs to
Be effective
A similar number of d2 receptors in other areas of the brain must also be blocked

Question 17

Typical antipsychotics side effects

Answer 17

tardive dyskinesia Involuntary movement of tounge face and jaw
Drugs affect the extrapyramidal area of the brain which helps to control motor activity

Question 18

Effect of atypical antipsychotics

Answer 18

Affect both positive and negative symptoms
Improve mood and cognitive functioning
Reducing anxiety and depression
Often provided to patients at risk of suicide