22 - 140 - ERYTHEMA ELEVATUM DIUTINUM

Question 1

Which of the following is false about EED?

A. The incidence of EED is unknown

B. Individual lesions of EED are round to oval, usually smooth and scaly

C. It may be asymptomatic

D. It may be associated with pruritus, pain, burning, stinging, paresthesia, or neuropathy

Answer 1

B

Question 2

Infections such as ______ can precipitate outbreaks of EED.

A. Staphylococcal

B. Streptococcal

C. Dermatophytic

D. Mycobacterial

Answer 2

B

Question 3

A hypothesis of the pathogenesis off EED _______ .

A. IgE mediated

B. Antibody mediated

C. Immune complex deposition

D. T-cell mediated

Answer 3

C

Question 4

Direct immunofluorescence studies of EED often reveal the non-specific deposition of __________ .

A. IgG and C3

B. IgA and IgM

C. Fibrin

D. All of the above

Answer 4

D

Question 5

First line agent in treatment of EED is ____ .

A. Dapsone

B. Tetracycline

C. Antihistamine

D. Colchicine

Answer 5

A

Question 6

type of EED more often seen in young women with a personal and/or family history rheumatism

Answer 6

“Bury-type”

Question 7

type of EED more often seen in older men with gout

Answer 7

Hutchinson-type

Question 8

clinical manifestions and areas of predilection of EED

Answer 8

EED typically first presents as edematous, erythematous to violaceous papules, nodules, and plaques, distributed relatively symmetrically upon the skin overlying the joints of the fingers, toes, and hands (Fig. 140-1), or upon the extensor surfaces, such as the elbows (Fig. 140-2), wrists, knees (Fig. 140-3), ankles, legs, and Achilles tendon.

Question 9

EED is associated with what conditions?

Answer 9

Question 10

the most frequent association with EED

Answer 10

IgA paraproteinemia

Question 11

central feature of disease process in EED

Answer 11

Leukocytoclastic vasculitis

Question 12

histopathologic findings of early EED

Answer 12

* neutrophilic infiltrates and neutrophilic pyknotic debris, as well as fibrin, surrounding the upper and middermal vascular plexii
* Lymphocytes, histiocytes, and even a few eosinophils, may accompany this neutrophilic infiltrate.

Question 13

histopath findings of leate EED

Answer 13

becomes progressively more fibrotic, and perhaps even sclerotic, on occasion

Question 13

Question 13

forst-line therapies of EED

Answer 13

Sulfone-based therapies, including dapsone and sulfapyridine

• Rapid improvement may transpire in the first 48 hours, with complete resolution of all lesions over weeks or months