21 - 133 - SKIN MANIFESTATIONS OF INTERNAL ORGAN DISORDERS

Question 1

Nail changes associated with cardiovascular disease

Answer 1

clubbing and the Quincke pulsation

Question 2

Quincke pulsation is indicative with what condition

Answer 2

aortic regurgitation

Question 3

result from immune complex deposition and are painful, tender, and located distally on the digital tufts

Answer 3

Osler nodes

perivasculitis or necrotizing vasculitis without microabscess formation

Question 4

nontender and located proximally on the palms and soles

Answer 4

Janeway lesions

vasculitis with microabscess formation

Question 5

Frank sign (cutaneous finding of a diagonal earlobe crease) has been (controversially) associated with an increased risk of ____________

Answer 5

coronary artery disease

Question 6

Answer 6

Question 7

most common cardiac manifestation of SLE, occurring in approximately 25% of patients during the course of their disease

Answer 7

Pericarditis

Question 8

Small vessel disease of the myocardium causing patchy fibrosis is a hallmark of __________

Answer 8

Systemic Sclerosis

Question 9

characterized by increased distal fingertip mass and longitudinal and transverse nail plate curvature

Answer 9

Digital clubbing

Question 10

angle between the nail plate and the proximal nailfold

Answer 10

Lovibond angle

Question 11

Lovibond angle in digital clubbing

Answer 11

greater than 180 degrees

Question 12

Lovibond angle in normal nail

Answer 12

less than 160 degrees

Question 13

most common intrathoracic manifestation of sarcoidosis

Answer 13

Bilateral hilar adenopathy

Question 14

Answer 14

Question 15

most common pulmonary manifestation of rheumatoid arthritis and appears to correlate with high levels of rheumatoid factor

Answer 15

Interstitial lung disease (ILD)

Question 16

Aquagenic wrinkling of the palms is associated with

Answer 16

cystic fibrosis

Question 17

Blue discoloration of the lunulae can be seen in

Answer 17

Wilson disease

Question 18

Koilonychia is associated with

Answer 18

hemochromatosis as well as iron deficiency anemia

Question 19

Jaundice becomes evident when total serum bilirubin levels are above

Answer 19

3

Question 20

Question 21

In GVHD, the most commonly affected organs are

Answer 21

skin, liver, and GI tract

Question 22

Kayser-Fleischer rings, which are brown or gray-green rings in the cornea is seen in what disorder

Answer 22

WILSON DISEASE

Question 23

Question 24

Answer 24

Question 25

most common cause of **pyoderma gangrenosum**, responsible for 25% to 50% of cases

Answer 25

**Inflammatory bowel disease (IBD)**

Question 26

characterized by a dull-white color proximally and a nonblanching red, pink, or brown color distally

Answer 26

**Lindsay nails (half-and-half nails)** seen frequently in patients on dialysis and resolve with renal transplantation

Question 27

Answer 27

Question 28

Quincke pulsation, which is flushing of the nail beds synchronous with the heart- beat, indicative of ____________ . E. Aortic regurgitation F. Mitral regurgitation G. Aortic stenois H. Mitral stenosis

Answer 28

Aortic regurgitation

Question 29

Which of the following does not describe Osler nodes? I. Result from immune complex deposition and are J. Located distally on the digital tufts, K. Non tender, non painful L. Perivasculitis or necrotizing vasculitis without microabscess formation

Answer 29

Non tender, non painful

Question 30

Small vessel disease of the myocardium causing patchy fibrosis is a hallmark of ___________ . M. SLE N. Ssc O. Ehlers-Danlos Disease P. Marfan Disease

Answer 30

Ssc

Question 31

The following are skin findings in eosinophilic granulomatosis with polyangiitis (Churg-Strauss) except ____________ . Q. Palpable purpura R. Livedo reticularis S. Pyoderma gangrenosum-like lesions T. Urticarial lesions

Answer 31

Pyoderma gangrenosum-like lesions

Question 32

Which of the following do not have a higher risk of ILD in DM? U. Anti-MDA-5 V. Anti-tRNA synthetase enzymes W. Anti-Jo-1 X. Anti-Mi-2

Answer 32

Anti-Mi-2

Question 33

Jaundice becomes evident when total serum bilirubin levels are ________ mg/dL . A. \>1.5 B. \>3 C. \>5 D. \>7

Answer 33

\>3

Question 34

This hereditary condition in which defective cellular copper transport leads to accumulation of copper in several organs—most commonly the \_\_\_\_\_\_\_\_\_\_\_\_. A. Lungs, liver, brain B. Heart, lungs, liver C. Kidney, heart, lungs D. Liver, brain, cornea

Answer 34

D. Liver, brain, cornea

Question 35

The most common organs involved in Kaposi sarcoma are ____________ . A. Heart and brain B. Vessels and kidneys C. GIT and lungs D. Eyes and GUT

Answer 35

C. GIT and lungs

Question 36

\_\_\_\_\_\_\_\_\_\_\_\_\_ are seen frequently in patients on dialysis and resolve with renal trans- plantation. A. Yellow nails B. Lindsay nails C. Terry nails D. Koilonychia

Answer 36

B. Lindsay nails

Question 37

\_\_\_\_\_\_\_\_\_\_\_\_ manifests on the skin with patchy alopecia and characteristic nail changes. A. Familial adenomatous polyposis B. Gardner syndrome C. Peutz-Jeghers D. Cronkhite-Canada syndromes

Answer 37

D. Cronkhite-Canada syndromes