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FITZPATRICK'S DERMATOLOGY 9TH EDITION (SHAMMY) > 17 - 97 - PHOTOTOXICIY AND PHOTOALLERGY > Flashcards

17 - 97 - PHOTOTOXICIY AND PHOTOALLERGY Flashcards

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Dermatology Board Prep flashcards
1
Q

occurs in anyone exposed to sufficient doses of phototoxic agent and UV radiation; it usually manifests as an exaggerated sunburn reaction

A

Phototoxicity

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2
Q

immune reaction to a UVA-modified chemical, commonly topical sunscreen agents and antimicrobials in the United States and the United Kingdom, and topical nonsteroidal antiinflammatory agents in Europe.

It presents as eczematous eruption on sun-exposed areas.

A

Photoallergy

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3
Q

result of direct tissue injury caused by the phototoxic agent and radiation. It can occur in all individuals exposed to adequate doses of the agent and the activating wavelengths of radiation

A

Phototoxicity

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4
Q

type IV delayed hypersensitivity response to a molecule that has been modified by absorption of photons

A

photoallergy

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5
Q

Most of the photosensitivity induced by systemic medications are

A

phototoxicity

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6
Q

induced by topical agents

A

photoallergy

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7
Q
A
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8
Q
A
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9
Q

Phototoxic Agents

A
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10
Q

Phototoxic Agents

A
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11
Q

Photosensitizing Agent

A
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12
Q

Asymptomatic blue-gray pigmentation on sunexposed areas is associated with exposure to several agents namely, _____

A

amiodarone, chlorpromazine, clozapine, imipramine and, less commonly, desipramine

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13
Q

most commonly reported causative agent of pseudoporphyria (The development of porphyria cutanea tarda–like cutaneous changes of skin fragility, vesicles, and subepidermal blisters is associated with several phototoxic agents)

A

Naproxen

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14
Q
A
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15
Q
A
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16
Q
A
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17
Q
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18
Q
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19
Q
A
20
Q

ACCELERATED PHOTOINDUCED CHANGES has been uniquely described with what drug

A

voriconazole

21
Q
A
22
Q
A
23
Q

In sensitized individuals, exposure to the photoallergen and sunlight results in the development of a pruritic, eczematous eruption within 24 to 48 hours after exposure

A

PHOTOALLERGY

24
Q

True or False: In photoallergy, the presence of both photoallergen and the activating wavelengths of radiation (UVA) are required

A

TRUE

25
Q

Vesicular and bullous eruptions are most commonly associated with

A

phototoxicity

26
Q

eczematous eruptions strongly suggest

A

photoallergy

27
Q

associated with a burning sensation

A

phototoxicity

28
Q

associated with pruritus

A

photoallergy

29
Q

necrotic keratinocytes are commonly seen in

A

phototoxicity

30
Q

spongiotic dermatitis is associated with

A

photoallergy

31
Q

Causative agents of photo-onycholysis, except (P.1658)

a. Doxycycline

b. Ciprofloxacin

c. Aripiprazole

d. Terbinafine

A

D

32
Q

Drugs that cause slate-gray pigmentation due to drugmetabolite melanin complex, except (P. 1658)

a. Amiodarone

b. Clozapine

c. Minocycline

d. Imipramine

A

C

33
Q

MC causative agent of pseudoporphyria (P. 1658)

a. Amiodarone

b. Cyclosporine

c. Naproxen

d. Voriconazole

A

C

34
Q

MC causative agent of accelerated photo-induced changes. (P. 1661)

a. Amiodarone

b. Cyclosporine

c. Naproxen

d. Voriconazole

A

D

35
Q

on phototesting, a substance has (+) reaction only at irradiated site. This is diagnosed as: (P. 1664)

a. Photoallergy

b. ACD

c. Photoallergy and ACD

d. Irritant reaction

A

A

36
Q

on phototesting, a substance has (+) reaction on both covered and irradiated sites. This is diagnosed as: (P. 1664)

a. Photoallergy

b. ACD

c. Photoallergy and ACD

d. Irritant reaction

A

B

37
Q

on phototesting, a substance has (+) reaction on both covered and irradiated sites but with higher intensity at the irradiated site. This is diagnosed as: (P. 1664)

a. Photoallergy

b. ACD

c. Photoallergy and ACD

d. Irritant reaction

A

C

38
Q

on phototesting, a substance has (+) reaction consisting of a well-defined erythema that resolves (P. promptly. This is diagnosed as: (P. 1664)

a. Photoallergy

b. ACD

c. Photoallergy and ACD

d. Irritant reaction

A

D

39
Q

This substance is an exception to the normal kinetics of acute phototoxicity since acute response first appears after 24 hours and peaks at 24-72 hours (P. 1657)

a. PUVA

b. MAL

c. Fluorescein

d. Tar

A

A

40
Q

this part of the nail serves as a lens to focus energy in cases of photo-onycholysis (P. 1658)

a. Nail plate

b. Nail bed

c. Nail matrix

d. Lunula

A

A

41
Q

what type of UVR usually cause photosensitivity

A

UVA

42
Q
A
43
Q

PHOTODISTRIBUTED TELANGIECTASIA is associated with what drugs

A

calcium channel blockers, including nifedipine, amlodipine, felodipine, and diltiazem, with the antibiotic cefotaxime, and with the antidepressants venlafaxine and escitalopram

44
Q

LICHENOID PHOTOSENSITIVE ERUPTION is associated with what drugs

A

doxycycline, capecitabine

45
Q

These drugs induce exaggerated UV response as a result of their irritant effect on the skin

A

Fluorouracil and retinoids

FITZPATRICK'S DERMATOLOGY 9TH EDITION (SHAMMY) (122 decks)

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