16 - 86 - TELOGEN EFFLUVIUM Flashcards
characterized by increased telogen club hair shedding
Telogen effluvium
TE is best characterized by a premature termination of the anagen (growing) phase of hair follicles, with a resultant increase in telogen (resting) phase hairs leading to excessive and diffuse loss of club hairs
most common cause of diffuse hair loss
Telogen effluvium
triggers of telogen effluvium
febrile diseases, childbirth, emotional disturbance, chronic systemic diseases, or the administration of heparin
the loss of more than how many percent of scalp hairs has been reported to be necessary to clinically detect diffuse hair loss?
more than 25%
Irrespective of clinical subtypes, what the most representative manifestation of TE?
diffuse excessive shedding of club hairs
in acute TE, acute and diffuse hair shedding is noted how many months from causative events?
2 to 4 months
Usually gradual decrease and termination of hair shedding and the regrowth of new anagen hairs in acute TE can be expected by how many months?
3 to 6 months.
chronic diffuse telogen hair loss occurs more than how many months?
more than 6 months
give exemples of causes of acute TE
- Effluvium of the newborn
- Febrile illness
- Surgery
- Pregnancy
- Weight loss (crash diet)
- Drugs (may cause CDTHL)
causes of Chronic diffuse telogen hair loss (CDTHL)
- Thyroid disease
- Aging Malnutrition
- Iron deficiency (controversial)
- Zinc deficiency (severe cases)
- Systemic illness
- Psychological stress (controversial)
- STD (HIV infection and syphilis)
The relation between CDTHL and the causative factors needs to be reversible and reproducible.
cause of Chronic telogen effluvium
Idiopathic (shortening of anagen)
On average, telogen hair accounts for around how many % of scalp hairs?
10% (Normal)
in effluvium of the Newborn, the shedding starts within how many months after birth?
4 months
This type of effluvium may be regarded as “total replacement of the first pelage completed before the first 6 month of life.
effluvium of the Newborn
after a febrile illness, hair shedding appears how many months after the illness and continued for how many weeks?
Hair shedding appeared 3 to 4 months after the illness and continued for 3 to 4 weeks
Postpartum alopecia or telogen gravidarum is probably the most widely recognized form of classic TE observed how many months after childbirth?
2 to 3 months
thyroid disease associated with TE
Hair regrowth can be observed around how many weeks after the initiation of thyroid hormone replacement?
hypothyroidism
8 weeks
A vigorous weight loss (11.7 to 24.75 kg within 3 weeks to 3 months) can result in remarkable increase in telogen counts (25% to 50%) and lead to acute TE.
Calorie restriction of how many kcal per day has been reported to be associated with hair loss?
0 to 1200
represents a main mechanism of drug-induced TE
Early entry of anagen hair follicles into telogen
In many cases of drug-induced TE, the shedding starts how manymonths after the initiation of the medication?
2 - 3 months
Usually, the recovery from TE can be expected around 3 months after the termination of a causative drug
Identify the mechanism/ pathophysiology of TE involved
Identify the mechanism/ pathophysiology of TE involved
anagen period is prolonged in most hair follicles but eventually terminated, resulting in an abrupt increase in telogen hairs
DELAYED ANAGEN RELEASE
Identify the mechanism/ pathophysiology of TE involved
febrile illness
IMMEDIATE ANAGEN RELEASE
Identify the mechanism/ pathophysiology of TE involved
drug- or stress-induced TE respectively represented by those induced by heparin and drugs in the heparin family
IMMEDIATE ANAGEN RELEASE
Premature termination of anagen and entry into telogen
Identify the mechanism/ pathophysiology of TE involved
postpartum period
DELAYED ANAGEN RELEASE
Identify the mechanism/ pathophysiology of TE involved
TE may result from earlier entry into anagen as the frequency of hair shedding should increase
IMMEDIATE TELOGEN RELEASE
Identify the mechanism/ pathophysiology of TE involved
etretinate-treated patients
SHORT ANAGEN
- idiopathic anagen shortening could be observed in some individuals
- shorter anagen results in a higher telogen rate, with resultant effluvium
Identify the mechanism/ pathophysiology of TE involved
initiation of topical minoxidil
IMMEDIATE TELOGEN RELEASE
Identify the mechanism/ pathophysiology of TE involved
The telogen phase is sustained in this case but immediately after, the anagen is initiated, resulting in an increase in shedding club hairs
DELAYED TELOGEN RELEASE
Identify the mechanism/ pathophysiology of TE involved
seasonal molting in mammals and, probably, in humans traveling from low-daylight to high daylight conditions
DELAYED TELOGEN RELEASE
Identify the mechanism/ pathophysiology of TE involved
term during which club hairs are shed from the telogen root sheath sac
Exogen
