25 - 167 - HUMAN PAPILLOMAVIRUS INFECTIONS

Question 1

Common warts are caused most frequently by what HPV types?

Answer 1

HPV 2/27/57/4

Question 2

Plantar and palmar warts are commonly caused by what HPV type

Answer 2

HPV 1

may be called myrmecia.

Question 3

Butcher’s warts

Answer 3

HPV 7

Question 4

Flat warts are usually caused by what HPV type

Answer 4

HPV 3 or 10 (28)

Question 5

HPV-1 warts are found only on what body part?

Answer 5

Palms and soles (and may be called mymecia)

Question 6

Untreated, warts in young people usually clear spontaneously within about about how many years

Answer 6

2 years, and only a few remain at 4 years

Question 7

In verruca, regular treatment for at least how many months or longer is likely to be required?

Answer 7

At least 3 months

Question 8

How do you use cryotherapy in verruca

Answer 8

Cryotherapy with liquid nitrogen is best used as a double freeze, repeated every 3 weeks for at least 3 months

Question 9

Question 10

Most common causative agents in anogenital warts

Answer 10

HPV 6 and 11

Question 11

First line of therapy for anogenital warts

Answer 11

Anogenital warts are usually treated with a topical application as first-line therapy.

Podophyllotoxin or imiquimod are both self-applied treatments with a 50% to 70% clearance rate.

—————
Anogenital warts, Perianal warts
MIMS Dosage
Adult:
As 3.75% cream: Apply thinly onto affected area once daily until total clearance or for a Max duration of 8 weeks.

As 5% cream: Apply 3 times weekly (non-consecutive days) for up to 16 weeks.

Question 12

Question 13

T/F

HPVs only infect humans

Answer 13

True

HPVs only infect humans and, in particular, epithelial keratinocytes.

Question 14

New infection occurs when the virus particle contacts what part of the epidermis?

Answer 14

basal epidermal keratinocyte, presumed to be via small microabrasions in the skin or mucosa

Question 15

These proteins are pivotal to the process of viral genome amplification

Answer 15

E6 and E7 proteins

Question 16

HPV in Periungual SCC

Answer 16

HPV 16

Question 17

HPV in oral and anogenital warts

Answer 17

6,11

Question 18

HPV in SCC of the mouth and pharynx

Answer 18

16 (18, 31, 33, 35 and others)

Question 19

HPVs that have been found in epidermoid plantar cysts of Japanese patients

Answer 19

HPV-57 and -60

Question 20

histopath findings of warts

Answer 20

• The histology is of **acanthosis, hypergranulosis, and hyperkeratosis **of the epidermis.
• The keratinocytes of the upper granular layer may show koilocytosis with clear cytoplasm and a dense twisted nucleus

Question 21

Question 22

• rare, heritable skin disorder with a mild underlying primary immunodeficiency
• Widespread flaky, scaly, or flat warty lesions are seen on the face, hands, and forearms and other sun-exposed sites
• There is often erythema, hyperpigmentation, or more rarely hypopigmentation of lesions, and there can be confusion with pityriasis versicolor and plane warts
• In early adult life, actinic keratoses, Bowen disease, and invasive squamous cell carcinoma (SCC) can develop at affected sites

Answer 22

Epidermodysplasia verruciformis (EV)

Question 23

EV can be inherited in what pattern of inheritance

Answer 23

AR

The genes implicated most commonly are EVER-1 and -2, which produce the transmembrane, zinc-containing proteins TMC6 and TMC8

Question 24

Conditions That May Lead to Acquired Epidermodysplasia Verruciformis

Answer 24

Question 25

most common causative agents of anogenital warts

Answer 25

HPV-6 or -11

Question 26

HPV type associated with Anogenital intraepithelial neoplasia (AGIN)

Answer 26

HPV-16,

Question 27

In patients with Anogenital intraepithelial neoplasia (AGIN), treatment of choice for single lesions if the site is easily operable but may not be best for multifocal or multicentric disease

Answer 27

surgery