5 - 35 - SARCOIDOSIS

Question 1

MC organ affected in sarcoidosis

Answer 1

lungs

Question 2

most common presentation of sarcoidosis

Answer 2

papular form

Question 3

Symmetric, violaceous, indurated plaques and nodules on nose, earlobes, cheeks, and digits

Answer 3

Lupus Pernio

Question 4

Sarcoidal granulomas on MUCOSAL SURFACE and TONGUE, with bilateral enlargement of the lacrimal, parotid, sublingual, and submandibular glands

Answer 4

Mikulicz Syndrome

Question 5

Presents as persistent SUBCUTANOEUS NODULES that may be tender or painless; occurs on extremities

Answer 5

Darier-Roussy Sarcoid

Question 6

Erythema nodosum with** bilateral hilar adenopathy, arthralgia, and fever;** often the presenting manifestation of sarcoidosis

Answer 6

Lofgren Syndrome

Question 7

Fever, parotid gland enlargement, facial palsy, and anterior uveitis

Answer 7

Heerfordt syndrome

Question 8

most common complaint in sarcoidosis

Answer 8

cosmetic disfigurement

Question 9

This distinctive clinical variant is associated with a higher incidence of systemic involvement and upper respiratory tract disease

Answer 9

Lupus Pernio

Question 10

main NONSPECIFIC cutaneous manifestation of sarcoidosis

Answer 10

Erythema nodosum

Question 11

frequently the initial manifestation of sarcoidosis

Answer 11

Lofgren syndrome

Erythema nodosum with bilateral hilar adenopathy, arthralgia, and fever

These patients tend to have an acute form of sarcoidosis with eventual resolution.

Question 12

most common manifestation or involvement of ocular sarcoidosis

Answer 12

Uveitis

Question 13

most common manifestation of neurosarcoidosis

Answer 13

cranial neuropathies

Question 14

cranial nerve most frequently involved in neurosarcoidosis

Answer 14

facial nerve

Question 15

Risk factors for sarcoidosis

Answer 15

• infectious agents:** Mycobacterium, P.acnes, Chlamydia **
• Mineral dusts - silica, iron and titanium
• Increase risk: firefighters and those that use wood burning stoves
• Lifelong nonsmokers are more likely to develop the disease
• genetic susceptibility

Question 16

reflect the total granuloma burden in sarcoidosis

Answer 16

serum angiotensin-converting enzyme (SACE) levels

• epithelioid cell of the sarcoidal granuloma secretes angiotensin-converting enzyme
• SACE levels are elevated in all granulomatous diseases, including infectious ones

Question 17

this finding on chest radiograph almost always represent sarcoidosis

Answer 17

Asymptomatic hilar adenopathy

Question 18

These findings in gallium-67 scanning is highly specific for sarcoidosis

Answer 18

panda sign (bilateral lacrimal and parotid gland uptake)

lambda sign (bilateral hilar and right paratracheal uptake)

Question 19

bilateral lacrimal and parotid gland uptake in gallium-67 scanning

Answer 19

Panda sign

Question 20

bilateral hilar and right paratracheal uptake in gallium-67 scanning

Answer 20

Lambda Sign

Question 21

most reliable immediate initial therapy for sarcoidosis

Answer 21

Systemic corticosteroids

Question 22

Liver biopsies should be considered in patients after how many grams of methotrexate?

Answer 22

1 - 2 g

Question 23

useful for sarcoidosis affecting the joints and skin, and hypercalcemia

Answer 23

Antimalarial drugs

Question 23

These agents are not highly effective for pulmonary disease,

Answer 23

Antimalarial drugs

Question 24

Sarcoid Medical Therapy

Answer 24