2 - 15 - EPIDERMAL AND DERMAL AHDESION Flashcards
major cell adhesion junction of the epidermis, serving to anchor apposing keratinocyte cell surface membranes to the intracellular keratin intermediate filament network
desmosome (or macula adherens)
intercellular space between plasma membranes
desmoglea
major desmoglein isoform in most simple and transitional epithelia, as well as cardiac myocytes
Dsg2
prominent in desmosomes of the hair follicle, testis, and prostate
Dsg4
only desmocollin isoform in cardiac tissue
Dsc2
most strongly expressed in the stratified squamous epithelia of the skin and oropharynx
Dsc3, Dsg3
target of pathologic proteolytic cleavage in the infectious disorders bullous impetigo and staphylococcal scalded skin syndrome, as well as the inherited ichthyosis associated with Netherton syndrome
Desmoglein 1
Pathogenic autoantibodies to desmoglein 1 are found in what diseases?
pemphigus foliaceus, mucocutaneous pemphigus vulgaris, and paraneoplastic pemphigus
target of pathogenic autoantibodies in mucosal and mucocutaneous pemphigus vulgaris and paraneoplastic pemphigus
Desmoglein 3
target of autoantibodies in subcorneal pustular dermatosis-type immunoglobulin A pemphigus
Desmocollin 1
the major component of the hemidesmosomal inner dense plaque
230-kDa bullous pemphigoid antigen 1, or BP230
major laminin of the epidermal basement membrane
laminin 332
major antigen in bullous pemphigoid
180-kDa bullous pemphigoid antigen 2, BP180, collagen XVII
anchoring filament components
laminin 332 and the ectodomain of collagen XVII
major component of the anchoring fibrils
Collagen VII
In the acquired form of epidermolysis bullosa, epidermolysis bullosa acquisita (Chap. 56), and in bullous systemic lupus erythematosus, autoantibodies target mainly what structure?
NC-1 domain of collagen VII
