21 - 134 - CUTANEOUS PARANEOPLASTIC SYNDROMES

Question 1

Answer 1

Question 2

Answer 2

Question 3

Question 4

Question 5

Question 6

Question 7

Question 8

Question 9

Question 10

Question 11

Question 12

Question 13

Question 14

Question 15

Question 16

Question 17

Elenita is a 50 year old female who came to you for consult of her skin lesions. You assessed that she has multiple acrochordons, fibrofolliculomas and trichodiscomas.

1. What is the major associated internal malignancy associated with her skin lesions?
   a. breast cancer
   b. colorectal cancer
   c. renal cancer
   d. medullary thyroid cancer p.2444 table 134-2
2. What other associated conditions should you investigate for?
   a. adrenocortical disease
   b. esophageal papillomas
   c. cerebellar dysfunction
   d. emphysema
   p. 2444 table 134-2

Answer 17

c. renal cancer

d. emphysema

Question 18

Rolando is a 40 year old male who came to you for consult for his skin lesions. You assessed that he has heliotrope rash, gottron papules, gottron rash as well as muscle pains.

3. Which is true regarding his disease?
   a. In adult patients with DM, the risk of malignancy is highest in the first 3-6 months after diagnosis
   b. It is associated with GI and respiratory tract cancer in females
   c. It is associated with nasopharyngeal cancer in Caucasians
   d. Its course does not always follow the course of malignancy
   p. 2453
4. Which of these organ malignancies is most commonly associated with the patient’s gender?
   a. hematologic
   b. renal
   c. GI
   d. lymphatic
   p. 2442 table 134-1

Answer 18

d. Its course does not always follow the course of malignancy
c. GI

Question 19

Necrolytic Migratory Erythema is associated with which major internal malignancy?

a. multiple myeloma
b. glucagonoma
c. Hodgkin lymphoma
d. hepatocellular carcinoma p.2442 table 134-1

Answer 19

b. glucagonoma

Question 20

Which set of paraneoplastic associated with lung cancer?
a. tripe palms, systemic sclerosis, erythema gyratum repens

b. erythema gyratum repens, scleromyxedema, sweet syndrome
c. sweet syndrome, tripe palms, erythema gyratum repens, multicentric reticulohistiocytosis
d. dermatitis herpetiformis, tripe palms, pyoderma gangrenosum, necrolytic migratory erythema p.2442 table 134-1

Answer 20

a. tripe palms, systemic sclerosis, erythema gyratum repens

Question 21

Which is true regarding Gorlin syndrome? a. associated with esophageal papillomas

b. can be associated with meningiomas and ovarian fibromas
c. associated with defect in the PRKAR1A gene

d. presents with epidermoid cysts, pilomatricomas and lipomas
p. 2442 table 134-2

Answer 21

b. can be associated with meningiomas and ovarian fibromas

Question 22

Which of these syndromes have an X-linked recessive inheritance?

a. xeroderma pigmentosum
b. maffucci syndrome
c. dyskeratosis congenita

d. Werner syndrome
p. 2446 table 134-2

Answer 22

c. dyskeratosis congenita

Question 23

What is the most common site for cutaneous metastasis?

a. scalp
b. face
c. genitals
d. thorax

Answer 23

d. thorax

Question 24

What is the most frequent clinical manifestation of Trousseau syndrome?

a. venous thromboembolism
b. pulmonary embolism
c. superficial migratory thrombophlebitis
d. marantic endocarditis

Answer 24

a. venous thromboembolism