20 - 120: CUTANEOUS PSEUDOLYMPHOMA Flashcards
This disease clinically presents with a nodule or plaque on the face, especially the nose and cheeks, and is histologically characterized by dense nodular infiltrate, predominantly located in the reticular dermis, reactive germinal centers with tangible body macrophages, small lymphocytes, and scattered plasma cells.
B cell pseudolymphoma
This disease clinically presents as solitary or multiple nodules and plaques more often on the head and neck, and histologically appears as nodular infiltrates with neoplastic germinal centers with tumor cells with centrocyte-like differentiation and few plasma cells.
Primary cutaneous follicle center lymphoma
This disease clinically presents as solitary or multiple nodules frequently seen on the upper trunk, and is characterized by nodular infiltrates with reactive germinal centers with tangible body macrophages, tumor cells with lymphoplasmacytoid differentiation, and plasma cells in small sheets.
Primary cutaneous marginal zone lymphoma
Treatment of nodular pseudolymphoma includes the following except?
a. Avoidance or elimination of the causative agent
b. Antibiotic treatment for infection-associated pseudolymphoma
c. Surgical excision, cryotherapy, laser treatment
d. Topical/intralesional steroids
e. None of the above
e. None of the above
This disease is characterized by lesions that are distributed on the lower back or over areas that have been treated for hematoma after trauma or surgery
a. Borrelia-induced B-cell pseudolymphoma
b. Lymphomatoid drug eruption
c. Pseudolymphoma caused by hirudo medicinalis therapy
d. Actinic reticuloid
Answer: C
This disease presents with persistent erythematous lichenoid papules and plaques on light-exposed skin areas, particularly on the face and neck. Leonine facies are also present.
Actinic reticuloid
This disease manifests with disseminated solid papules wherein the coalescing brownish papules are flat-topped and observed mainly on the flexor surfaces of the extremities.
Papuloerythroderma of ofuji
This disease manifests as a unilateral eruption of clustered red to violaceous angiomatous papules (diameter: 1 to 5 mm) on hands and feet of children
Acral pseudolymphomatous angiokeratoma
This disease represents a proliferation of blood vessels with prominent endothelia accompanied by a dense infiltrate of T-cells and B-cells in conjunction with eosinophils
Angiolymphoid hyperplasia with eosinophilia (ALHE)
This is a benign lymphoproliferative disorder with 2 variants: the hyaline vascular type and the plasma cell variant and most commonly is located in the lymph nodes (mediastinal or generalized) and rarely affects the skin.
Castleman disease
bacterial infection associated with pseudolymphoma
Borrelia burgdorferi
preferred sites for Borrelia-induced B-cell PSLs
face and scalp, and especially the earlobes, nipples, and scrotum
what color of tattoos have been associated with pseudolymphoma?
red, green and blue
most commonly used dye for red tattoos
Cinnabar, a mercuric sulfide
In tattoos, the lymphocytic infiltrates mostly arise and remain limited to areas with red tattoo dye
- manifests with disseminated solid papules.
- The coalescing brownish papules are flat-topped and observed mainly on the flexor surfaces of the extremities.
- The axillae, inguinal regions, antecubital and popliteal fossae, and big furrows on the abdomen are spared (“deckchair” sign)
Papuloerythroderma Ofuji
The most common abnormal laboratory findings in Papuloerythroderma Ofuji
eosinophilia and an elevated serum IgE level
- unilateral eruption of clustered red to violaceous angiomatous papules (diameter: 1 to 5 mm) on acral sites, that is, hands and feet
- Longitudinal splitting of the nails, onycholysis, and nail deformities may occur.
Acral pseudolymphomatous angiokeratoma (APA)
- recently described rare skin disease that is considered to be a form of PSL of unknown etiology
- Longstanding plaque or circumscribed, often linear arranged, reddish and brownish papules and plaques
- Originally it was reported in children with the pretibial region as predilection site
- Histology reveals a dense dermal lymphohistiocytic infiltrate with numerous polyclonal plasma cells accounting for up to 25% of the entire infiltrate
- The infiltrate is superficial, bandlike, or deep nodular and interstitial, often accentuated around adnexal structures or blood vessels
Lymphoplasmacytic plaque (LPP)
