20 - 120: CUTANEOUS PSEUDOLYMPHOMA

Question 1

This disease clinically presents with a nodule or plaque on the face, especially the nose and cheeks, and is histologically characterized by dense nodular infiltrate, predominantly located in the reticular dermis, reactive germinal centers with tangible body macrophages, small lymphocytes, and scattered plasma cells.

Answer 1

B cell pseudolymphoma

Question 2

This disease clinically presents as solitary or multiple nodules and plaques more often on the head and neck, and histologically appears as nodular infiltrates with neoplastic germinal centers with tumor cells with centrocyte-like differentiation and few plasma cells.

Answer 2

Primary cutaneous follicle center lymphoma

Question 3

This disease clinically presents as solitary or multiple nodules frequently seen on the upper trunk, and is characterized by nodular infiltrates with reactive germinal centers with tangible body macrophages, tumor cells with lymphoplasmacytoid differentiation, and plasma cells in small sheets.

Answer 3

Primary cutaneous marginal zone lymphoma

Question 4

Treatment of nodular pseudolymphoma includes the following except?

a. Avoidance or elimination of the causative agent
b. Antibiotic treatment for infection-associated pseudolymphoma
c. Surgical excision, cryotherapy, laser treatment
d. Topical/intralesional steroids
e. None of the above

Answer 4

e. None of the above

Question 5

This disease is characterized by lesions that are distributed on the lower back or over areas that have been treated for hematoma after trauma or surgery

a. Borrelia-induced B-cell pseudolymphoma
b. Lymphomatoid drug eruption
c. Pseudolymphoma caused by hirudo medicinalis therapy
d. Actinic reticuloid

Answer 5

Answer: C

Question 6

This disease presents with persistent erythematous lichenoid papules and plaques on light-exposed skin areas, particularly on the face and neck. Leonine facies are also present.

Answer 6

Actinic reticuloid

Question 7

This disease manifests with disseminated solid papules wherein the coalescing brownish papules are flat-topped and observed mainly on the flexor surfaces of the extremities.

Answer 7

Papuloerythroderma of ofuji

Question 8

This disease manifests as a unilateral eruption of clustered red to violaceous angiomatous papules (diameter: 1 to 5 mm) on hands and feet of children

Answer 8

Acral pseudolymphomatous angiokeratoma

Question 9

This disease represents a proliferation of blood vessels with prominent endothelia accompanied by a dense infiltrate of T-cells and B-cells in conjunction with eosinophils

Answer 9

Angiolymphoid hyperplasia with eosinophilia (ALHE)

Question 10

This is a benign lymphoproliferative disorder with 2 variants: the hyaline vascular type and the plasma cell variant and most commonly is located in the lymph nodes (mediastinal or generalized) and rarely affects the skin.

Answer 10

Castleman disease